Genetic study of I kappa B alpha gene promoter polymorphism associated with hepatitis C virus in Egyptian patients
Ghazalah, M., El-Masry, S., Helmy, I., Abd-Elkhalek, E. (2022). Genetic study of I kappa B alpha gene promoter polymorphism associated with hepatitis C virus in Egyptian patients. EKB Journal Management System, 8(3), 154-162. doi: 10.21608/jbaar.2022.255496
Mamoun Kamal Ghazalah; Sameer El-Masry; Ibrahim Helmy; Ehab Abd-Elkhalek. "Genetic study of I kappa B alpha gene promoter polymorphism associated with hepatitis C virus in Egyptian patients". EKB Journal Management System, 8, 3, 2022, 154-162. doi: 10.21608/jbaar.2022.255496
Ghazalah, M., El-Masry, S., Helmy, I., Abd-Elkhalek, E. (2022). 'Genetic study of I kappa B alpha gene promoter polymorphism associated with hepatitis C virus in Egyptian patients', EKB Journal Management System, 8(3), pp. 154-162. doi: 10.21608/jbaar.2022.255496
Ghazalah, M., El-Masry, S., Helmy, I., Abd-Elkhalek, E. Genetic study of I kappa B alpha gene promoter polymorphism associated with hepatitis C virus in Egyptian patients. EKB Journal Management System, 2022; 8(3): 154-162. doi: 10.21608/jbaar.2022.255496

Genetic study of I kappa B alpha gene promoter polymorphism associated with hepatitis C virus in Egyptian patients

Journal of Bioscience and Applied Research
Volume 8, Issue 3, September 2022, Page 154-162  XML PDF (1.05 MB)
Document Type: Original Article
DOI: 10.21608/jbaar.2022.255496
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Authors
Mamoun Kamal Ghazalah email 1; Sameer El-Masry1; Ibrahim Helmy2; Ehab Abd-Elkhalek3
11. Department of Molecular Biology, Biogenetic engineering Research Institute, Sadat City University, Egypt
22. Department of Molecular Biology Faculty of Science, Kafr al-Sheikh University, Egypt
33. Department of Gastroenterology and Endoscopy, Faculty of Medicine, Mansoura University, Egypt
Abstract
Background: Host genetic polymorphism is one of the major unalterable major factors for HCV infection, NF-κB proteins play multiple roles in immune response and involve in HCV infection and progression.
Aim of the study: To investigate the associations between single nucleotide polymorphism (SNPs) in NF-Kb and the susceptibility as well as resolution of HCV infection. Patients and Methods:  This prospective case-control study was conducted at the physical examination center on 150 Egyptian population, including 50 uninfected control cases, 50 cases with spontaneous viral clearance, and 50 cases with persistent HCV infection, they are genotyped for four SNPs (rs11820062, rs230530, rs1056890 and rs3774963) using a Taq Man assay.  Results: The current study revealed that the mutation in rs_11820062 of the I kappa B alpha gene significantly increased the risk for HCV infection with a p-value <0.05. Conclusion: This study revealed that genetic variants of the NF-κB pathway genes (rs11820062 T allele) are associated with an increased risk of HCV susceptibility.
Keywords
Recombinant immune blot assays; Single nucleotide polymorphisms; Nuclear factor of Kappa light polypeptide gene enhancer in B-cell
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