Study of The Role of Soluble Mannose Receptor (sMR/sCD206) in Multiple Myeloma | ||||
| Benha Medical Journal | ||||
| Article 8, Volume 39, Issue 3, November and December 2022, Page 850-857 PDF (512.78 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bmfj.2022.143008.1603 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Fetnat Mahmoud Tolba1; Hoyda Mohamed Kamal2; Alshimaa Alhanafy3; Radwa Salah Abdel Shafy  4; amira Mohamed Noureldin Abdelrahman5
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| 1clinical & chemical pathology dep., Faculty of Medicine, Benha university , Egypt | ||||
| 2Clinical and chemical pathology department, Benha Faculty of Medicine, Benha university, Benha, Egypt | ||||
| 3Clinical Oncology and Nuclear Medicine Faculty of Medicine -Menoufia University | ||||
| 4Clinical pathology, Faculty of medicine,Benha University | ||||
| 5Clinical and chemical pathology Faculty of Medicine, Benha University | ||||
| Abstract | ||||
| Background: Multiple Myeloma is an incurable B cell tumor characterized by the accumulation of malignant plasma cells in the bone marrow (BM). Objective: to assess serum level of soluble mannose receptor (sMR/CD206) in multiple myeloma patients and to predict its role in pathogenesis of multiple myeloma. Methods: A case- control study was conducted on thirty Egyptian patients (15 males and 15 females; their age ranged between 40-73 years) diagnosed with multiple myeloma and twenty race and sex matched healthy controls. Patients attending the clinical oncology and nuclear medicine department ,Faculty of medicine , Menofia University. Informed consent was obtained from the patients and this study was approved by local ethical committee of Faculty of medicine, Menofia University and Benha University Hospital. Results: All studied MM cases were evaluated, 26.6% had ISS I, 40% had ISS II and 33.3% had ISS III. Hemoglobin level was significantly lower in MM cases when compared to control group (P0.05 for each). MM patients had significantly higher sMR level when compared to control group at diagnosis (P value | ||||
| Keywords | ||||
| Multiple Myeloma; sMR; CD206 | ||||
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