KIDNEY FUNCTIONS AND SOME BLOOD CONSTITUENTS IN BROILER CHICKS AS INFLUENCED BY DIETARY AFLA TOXINS. | ||||
| Journal of Animal and Poultry Production | ||||
| Article 11, Volume 27, Issue 7, July 2002, Page 4553-4564 PDF (1.52 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jappmu.2002.255887 | ||||
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| Authors | ||||
| A. M. Abdel-Maksoud,1; E. F. EI-Daly2; S. M. Khashabah3; M. A. Galal3 | ||||
| 1Dept. Poult. Prod., Fac • of Agric., Ain Shams University | ||||
| 2National Res. Center, Dokki, Cairo. | ||||
| 3Animal Prod. Res. Instit., Agric. Res. Center, Ministry of Agriculture. | ||||
| Abstract | ||||
| An experiment was conducted to study the effects of anatoxin 81 (AFB1) supplementation on kidney function, performance, some blood constituents, some digestive organs (Liver, proventriculus and gizzard) and immune glands (spleen, thymus & bursa of Fabricius) of broiler chicks. A total of 135 one-day old broiler chicks were utilized during the whole experimental period (7 weeks of age). Birds were randomly assigned to three experimental groups. The first groups were fed the basal diet supplemented with AFB1 at a rate of !-Ig/kg diet, respectively. Supplementation of AFB1 resulted in a significant (P<O.05) reduction in body weight, weight gain, feed consumption and feed conversion ratio while resulted in a significant (P<O.01) increase in mortality rate. Regardless of age, the reduction in body weight and weight gain, and the elevation in mortality rate were increased as supplemental AF81 dose increased. Birds fed AFB1·supplemented diets exhibited a significant (P<O.05) increase in the relative weights of liver, kidney, proventriculus and gizzard while they showed a significant (P<O.05) decrease in the relative weight of spleen, thymus and bursa of Fabricius glands, this indicating immune suppression effect of AFB1. Uric acid in blood, creatinine, alkaline phosphatase, GOT and GPT were significantly (P<O.05) increased while plasma total protein, calcium, phosphorus and creatine Kinase were significantly (P<O.05) decreased by AF81 feeding, whicl'. reflects nutrient and mineral metabolism disorders and kidney dysfunction. AF81 had also acute and direct negative effect on glomerular filtration rate, urine now and Ca and P excretion in urine. This is coincident with the increased water consumption ano excreta moisture. It is concluded that AFB1, the most potent nephrotoxic for birds, act directly on the kidneys to alter several hematological parameters and nutrient and mineral metabolism in chickens. | ||||
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