THE EFFECTS OF ONION AND GARLIC JUICE ON BIOCHEMICAL PARAMETERS OF ALLOXAN·INDUCED DIABETIC RATS | ||||
| Journal of Food and Dairy Sciences | ||||
| Article 3, Volume 27, Issue 7, July 2002, Page 4779-4789 PDF (1.3 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jfds.2002.255921 | ||||
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| Author | ||||
| Hend M. A. Bakhashwin | ||||
| Faculty of Education for Home Economics and Art Education, Riad | ||||
| Abstract | ||||
| The present study was carried out to investigate the effects of onion (Allium cepa Unn) and garlic intake (allium sativum) on blood hematology, protein and lipid profile in alloxan-induced diabetic rats. A dose of 1 ml of onion or garlic juicesl100 g body weight was orally administered daily to alloxan-diabetic rats for four weeks. The present study showed 3-fold increase (p < 0.05) in the plasma glucose level of diabetic rats. which received alloxan as a single dose of 120 mgl1lg body weight relative to the mean value of control group. This elevated glucose level was restored to its normal level after treatment with onion and/or garlic. Body weight was Significantly (p < 0.05) decreased in diabetic rats. Relative weights of liver. lung, heart and kidney increased, while spleen and testes decreased. Hemoglobin (Hb), total erythrocyte count (TEC), packed cell volume (PCV) and total leukocyte count (TLC) were significantly (p < 0.05) decreased in diabetic rats. The concentrations of total protein (TP), albumin (A) and globulin were significantly (p < 0.05) decreased in diabetic rats compared to the control group. Furthermore, the levels of total lipids (TL), triglyceride (TG). cholesterol. low density lipoprotein (LOL) and very low lipoprotein (VLOL) were significantly (p < 0.05) increased in diabetic rats compared to the control group. whereas high density lipoprotein (HOL) level was significantly (p <0.05) decreased. Treatment of diabetic rats with repeated doses of onion and/or garlic could restore the changes of these parameters to their normal levels. The present results showed that onion and/or garlic exerted antihyperglycemic effects and consequently may alleviate the effects on hematological parameters, protein and lipid profile caused by alloxan-induced diabetes. | ||||
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