Multidrug-Resistant Gram-Negative ESKAPE Pathogens from a Tertiary-Care Hospital: Prevalence and Risk Factors
El-Kady, R., Karoma, S., Al Atrouni, A. (2022). Multidrug-Resistant Gram-Negative ESKAPE Pathogens from a Tertiary-Care Hospital: Prevalence and Risk Factors. EKB Journal Management System, 31(3), 135-142. doi: 10.21608/ejmm.2022.256008
Rania El-Kady; Sara Karoma; Ahmad Al Atrouni. "Multidrug-Resistant Gram-Negative ESKAPE Pathogens from a Tertiary-Care Hospital: Prevalence and Risk Factors". EKB Journal Management System, 31, 3, 2022, 135-142. doi: 10.21608/ejmm.2022.256008
El-Kady, R., Karoma, S., Al Atrouni, A. (2022). 'Multidrug-Resistant Gram-Negative ESKAPE Pathogens from a Tertiary-Care Hospital: Prevalence and Risk Factors', EKB Journal Management System, 31(3), pp. 135-142. doi: 10.21608/ejmm.2022.256008
El-Kady, R., Karoma, S., Al Atrouni, A. Multidrug-Resistant Gram-Negative ESKAPE Pathogens from a Tertiary-Care Hospital: Prevalence and Risk Factors. EKB Journal Management System, 2022; 31(3): 135-142. doi: 10.21608/ejmm.2022.256008

Multidrug-Resistant Gram-Negative ESKAPE Pathogens from a Tertiary-Care Hospital: Prevalence and Risk Factors

Egyptian Journal of Medical Microbiology
Volume 31, Issue 3, July 2022, Page 135-142  XML PDF (386.34 K)
Document Type: New and original researches in the field of Microbiology.
DOI: 10.21608/ejmm.2022.256008
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Authors
Rania El-Kady email 1; Sara Karoma2; Ahmad Al Atrouni3
1Department of Medical Microbiology and Immunology, Faculty of Medicine, Mansoura University
2Fakeeh College for Medical Sciences, Jeddah, KSA
3Microbiology Laboratory, Dr. Soliman Fakeeh Hospital, Jeddah, Kingdom of Saudi Arabia
Abstract
Background: Antibiotic-resistant ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) are commonly implicated in health-care associated infections (HAIs). Objectives: The purpose of this study is to assess the antimicrobial susceptibility profile of Gram-negative ESKAPE pathogens, with prime emphasis on the prevalence and risk factors for infections by multidrug-resistant (MDR) strains. Methodology: In this retrospective cohort study, we reviewed the electronic medical and laboratory records of our tertiary health-care facility throughout the period from January 2019 to December 2020. Adult patients identified with infections by any of the Gram-negative ESKAPE bacteria were eligible for our study. The risk factors associated with acquisition of MDR organisms were analyzed using univariate and multivariate models. Results: During the period of interest, a total of 614 Gram-negative ESKAPE isolates were identified, of which 121 were found to be MDR (19.7%). A. baumannii was the leading MDR organism (43.1%), whereas MDR P. aeruginosa was the least common (10.7%). The independent risk factors associated with acquisition of MDR infections included long hospital stays (P < 0.0001), undergoing surgical procedures (P= 0.001), ischemic heart disease (P= 0.005), mechanical ventilation (P= 0.005), and presence of indwelling urinary catheter (P= 0.03). Conclusions: Infections with MDR Gram-negative ESKAPE organisms have an alarming magnitude in our institution. Continued vigilance by the involved health-care workers, stringent compliance to the infection control guidelines, and effective implementation of the antimicrobial stewardship programs are critical measures to decrease the burden of this health problem.
Keywords
ESKAPE; pathogens; antimicrobial; MDR; Gram-negative; risk factors; ESBL
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