Inflammatory Markers for Predicting Ischemic Stroke Outcome: Review Article | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 7, Volume 89, Issue 1, October 2022, Page 4187-4190 PDF (493.3 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2022.256320 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Eman M. Khedr; Ayman Gamea; Islam Gadelrab Ahmed; Amira Khalifa Ismail 
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| Abstract | ||||
| Background: In developed countries, stroke is the third leading cause of mortality and the leading cause of lifelong disability. Chronic inflammation, oxidative and nitrosative damage to the immune, metabolic and cellular systems and, neurotoxicity therefore has a role in acute ischemic stroke (IS). It may be possible to employ various biomarkers simultaneously to forecast the occurrence and prognosis of IS. When inflammation subsides after a stroke, it accelerates tissue repair and neurodegenerative processes, which are known to expand the ischemic lesion. Post-stroke inflammation has a substantial impact on a patient's capacity to recover from the disease, and novel diagnostic, prognostic, and therapeutic treatments are urgently needed. Objective: An overview of the role of inflammation in stroke pathology is provided in the following review. Stroke patients' prognosis can be better predicted by using biomarkers of inflammation. Material and methods: These databases were searched for articles published in English in 3 data bases [PubMed – Google scholar - Science direct] and Boolean operators (AND, OR, NOT) had been used such as [Ischemic stroke OR Neuroinflammation AND Stroke outcome] and in peer-reviewed articles between Jun 2001 and November 2021; a 20-year date range was selected. Documents in a language apart from English have been excluded as sources for interpretation Conclusion: Clearly, inflammation is a major contributor to stroke pathogenesis. Inflammation plays a dual role during an ischemic stroke, showing both positive and detrimental effects depending on the stage of the disease. Stroke prognostication is hampered by the absence of sensitive and speedy blood tests for diagnosis. | ||||
| Keywords | ||||
| Ischemic stroke; Neuroinflammation; Stroke outcome | ||||
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