Efficient One-pot microwave-assisted Synthesis and Spectroscopic Characterization of Novel Antitumor and Antimicrobial Hydroxypyrrolidin2-ones
mohamed azmy, E., Awad, B., Hefni, H., Saad, H., Eltoukhy, A., Mabied, A. (2018). Efficient One-pot microwave-assisted Synthesis and Spectroscopic Characterization of Novel Antitumor and Antimicrobial Hydroxypyrrolidin2-ones. EKB Journal Management System, 35(part 1), 203-217. doi: 10.21608/jsrs.2018.25663
eman azmy mohamed azmy; Boshra M. Awad; Halima A. Hefni; Hanaa A. Saad; Affaf M. Eltoukhy; Ahmed. F. Mabied. "Efficient One-pot microwave-assisted Synthesis and Spectroscopic Characterization of Novel Antitumor and Antimicrobial Hydroxypyrrolidin2-ones". EKB Journal Management System, 35, part 1, 2018, 203-217. doi: 10.21608/jsrs.2018.25663
mohamed azmy, E., Awad, B., Hefni, H., Saad, H., Eltoukhy, A., Mabied, A. (2018). 'Efficient One-pot microwave-assisted Synthesis and Spectroscopic Characterization of Novel Antitumor and Antimicrobial Hydroxypyrrolidin2-ones', EKB Journal Management System, 35(part 1), pp. 203-217. doi: 10.21608/jsrs.2018.25663
mohamed azmy, E., Awad, B., Hefni, H., Saad, H., Eltoukhy, A., Mabied, A. Efficient One-pot microwave-assisted Synthesis and Spectroscopic Characterization of Novel Antitumor and Antimicrobial Hydroxypyrrolidin2-ones. EKB Journal Management System, 2018; 35(part 1): 203-217. doi: 10.21608/jsrs.2018.25663

Efficient One-pot microwave-assisted Synthesis and Spectroscopic Characterization of Novel Antitumor and Antimicrobial Hydroxypyrrolidin2-ones

Journal of Scientific Research in Science
Article 19, Volume 35, part 1, August 2018, Page 203-217  XML PDF (639.41 K)
Document Type: Original Article
DOI: 10.21608/jsrs.2018.25663
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Authors
eman azmy mohamed azmy email 1; Boshra M. Awad2; Halima A. Hefni2; Hanaa A. Saad2; Affaf M. Eltoukhy2; Ahmed. F. Mabied3
1chemistry, faculty of women, ain shams university, cairo, egypt
2Department of Chemistry, Faculty of Women for Arts, Science, and Education, Ain Shams University, Heliopolis, Cairo, Egypt
3X-Ray Crystallography Lab., Solid State Physics Department, National Research Centre, Dokki, Giza, Egypt
Abstract
A microwave-assisted, chemoselective synthesis of the novel antitumor and antimicrobial (3E)-5-hydroxy-1-isopropyl-3-[(5-methyl-2-thienyl)methylene]-5-phenylpyrrolidin-2-one has been achieved via assisted microwave solvent-free one-pot reaction of (3E)-3-[(5-methyl-2-thienyl)methylene]-5-phenylfuran-2(3H)-one with amines, urea and thiourea. The products are obtained in significant purity, yield, and eco-friendly reaction conditions. The structural formula of the products is confirmed by their spectroscopic characterizations.  A mechanism is proposed in which an intramolecular nucleophilic attack takes place on the carbonyl carbon by the lone pair of electrons on the nitrogen atom, leading to ring closure with proton transfer to oxygen forming the hydroxyl group.
 
 
Keywords
microwave; antitumor; Antimicrobial; pyrrolidin-2-one; furan-2(3H)-one; urea; thiourea
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