Evaluation of urinary C-terminal cross-linked telopeptides of type II collagen CTX-II as a biomarker for early diagnosis of osteoarthritis in comparison to routine diagnostic methods

Ellaithy, Lamia Samir; Moselhi, Mohamed; El Gazzar, Ragaa; Amer, Nagat M.; Mansour, Taher Amin; Taha, Mona; Shaheen, Weam; Mohammed, Asmaa Mahmoud

doi:10.21608/ejchem.2022.147871.6424

	Evaluation of urinary C-terminal cross-linked telopeptides of type II collagen CTX-II as a biomarker for early diagnosis of osteoarthritis in comparison to routine diagnostic methods
Egyptian Journal of Chemistry
Volume 65, Issue 132, December 2022, Page 707-717 PDF (681.56 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2022.147871.6424
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Authors
Lamia Samir Ellaithy¹; Mohamed Moselhi²; Ragaa El Gazzar³; Nagat M. Amer⁴; Taher Amin Mansour⁵; Mona Taha ⁶; Weam Shaheen ⁷; Asmaa Mahmoud Mohammed ⁸
¹Researcher environmental & Occupational Medicine Department, Environment and Climate Change Research Institute, National Research Centre, Egypt.
²Professor of Occupational Health and Industrial Medicine, Department of Occupational Health and Industrial Medicine, High Institute of Public Health, Alexandria University, Egypt.
³Professor of Occupational Hygiene (Biological Monitoring), Department of Occupational Health and Industrial Medicine High Institute of Public Health, Alexandria University, Egypt.
⁴Professor of Public Health. Environmental &amp; Occupational Medicine Department- Division of Environmental Research- National Research Centre, Giza, Egypt
⁵Assistant Professor of Occupational Health and Industrial Medicine, Department of Occupational Health and Industrial Medicine, High Institute of Public Health, Alexandria University, Egypt.
⁶Environmental and Occupational Medicine department, National Research Center
⁷Professor of environmental health, Environmental and Occupational medicine department, NRC
⁸Department of Environmental and Occupational medicine, National Research Centre, Egypt.
Abstract
Background: Work-related musculoskeletal disorders (WRMSDs) are serious occupational health problems among workers worldwide. Aim of the study: evaluate urinary C‐ terminal telopeptide of collagen type II (CTX-II) as a biomarker for early diagnosis of osteoarthritis and compare results with those obtained by the routinely used methods. Subjects and methods: One hundred and eighty workers from the outpatient clinics of rehabilitation center in Cairo performing physically demanding and office jobs. One hundred and twenty three workers diagnosed with knee OA (Group I) and 57 workers were healthy (Group II). Clinical examination, X-rays and questionnaire were done. Erythrocyte sedimentation rate, high sensitive C reactive protein and human CTX-II were measured. Results: No statistical significant difference between CTX-II in osteoarthritis workers and age, residence, smoking status and sport practice. Marked increase of urinary CTX-II level was found in osteoarthritis workers compared to healthy group. A high significance difference between CTX-II level and Western Ontario and Mc master Universities Arthritis Index (WOMAC) index scores in osteoarthritis workers, in addition high levels were found among grade 4 osteoarthritis. Mean urinary level of CTX-II in osteoarthritis workers increased with increased work duration and total working hours. Conclusion: Urinary CTX-II can predict clinical diagnostic criteria and x-ray progression in osteoarthritis, so it can be used as a tool for diagnosis of knee OA.
Keywords
Key words: WRMSD; osteoarthritis; WOMAC index scores; X- ray; urinary CTX-II


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