Omics: Approaches and applications related to diagnosis, treatment, and control of parasitic diseases. Part I: Plasmodium spp. | ||||
| Parasitologists United Journal | ||||
| Article 2, Volume 15, Issue 2, August 2022, Page 144-153 PDF (406.1 K) | ||||
| Document Type: Review Article | ||||
| DOI: 10.21608/puj.2022.153848.1180 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Radwa Diab; Salwa Younis 
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| Medical Parasitology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt | ||||
| Abstract | ||||
| Over the last two decades, omics studies provide a revolutionary advance of datasets in the field of Medical Parasitology for understanding parasite system biology, host-parasite interactions, and phylogenetic analyses; i.e., genomics, transcriptomes, proteomics, metabolomics. Together with bioinformatics, genome-wide associated studies (GWASs) enabled scientists to identify diagnostic biomarkers, promising drug targets, and potential vaccine candidates for diagnosis, treatment, and protection against several neglected tropical diseases. Omics approaches are either structural (genomics) or functional (post-genomics). To survive, Plasmodium spp. are able to delete certain genes unessential for their survival and growth, enabling them to evade host immune response. In addition, they undergo antigenic variations that lead to gene mutations in enzymes controlling drug uptake. Previously unattainable goals, e.g., host immunoevasion, susceptibility or resistance to infection, drug resistance, novel drugs as well as prevention and control were achieved by omics studies powered by bioinformatics tools. This part of the present review aims to shed light on omics application outcomes regarding Plasmodium spp. | ||||
| Keywords | ||||
| bioinformatics; diagnostic biomarkers; drug target; malaria; novel drugs; omics; Plasmodium spp; vaccine candidates | ||||
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