Uterine Receptivity Assessed By Three Dimensional Ultrasound and Power Doppler in Women with Polycystic Ovary Syndrome Treated By Clomiphene Citrate Alone or Combined To Metformin
Amal A. Zidan, H. (2011). Uterine Receptivity Assessed By Three Dimensional Ultrasound and Power Doppler in Women with Polycystic Ovary Syndrome Treated By Clomiphene Citrate Alone or Combined To Metformin. EKB Journal Management System, 15(2), 38-42. doi: 10.21608/egyfs.2011.257275
Hanan A. Ghali, Amal A. Zidan. "Uterine Receptivity Assessed By Three Dimensional Ultrasound and Power Doppler in Women with Polycystic Ovary Syndrome Treated By Clomiphene Citrate Alone or Combined To Metformin". EKB Journal Management System, 15, 2, 2011, 38-42. doi: 10.21608/egyfs.2011.257275
Amal A. Zidan, H. (2011). 'Uterine Receptivity Assessed By Three Dimensional Ultrasound and Power Doppler in Women with Polycystic Ovary Syndrome Treated By Clomiphene Citrate Alone or Combined To Metformin', EKB Journal Management System, 15(2), pp. 38-42. doi: 10.21608/egyfs.2011.257275
Amal A. Zidan, H. Uterine Receptivity Assessed By Three Dimensional Ultrasound and Power Doppler in Women with Polycystic Ovary Syndrome Treated By Clomiphene Citrate Alone or Combined To Metformin. EKB Journal Management System, 2011; 15(2): 38-42. doi: 10.21608/egyfs.2011.257275

Uterine Receptivity Assessed By Three Dimensional Ultrasound and Power Doppler in Women with Polycystic Ovary Syndrome Treated By Clomiphene Citrate Alone or Combined To Metformin

The Egyptian Journal of Fertility of Sterility
Article 9, Volume 15, Issue 2 - Serial Number 11106352, December 2011, Page 38-42  XML PDF (1.96 MB)
Document Type: Original Article
DOI: 10.21608/egyfs.2011.257275
View on SCiNiTO View on SCiNiTO
Author
Hanan A. Ghali, Amal A. Zidan1, 2
11 Depatment of Obstetrics & Gynecology, Zagazig University
22 Department of Clinical Pathology, Zagazig University
Abstract
Objective: A prospective randomized single blinded study was carried out to examine
whether metformin when combined with clomiphene citrate (CC) had an added effect, if
any, on uterine receptivity.
Patients and Methods: Seventy seven egyptian women with polycystic ovary syndrome
(PCOS) aging between 20-35 years were randomized to 2 groups received either 100 mg
cc for 5 days alone, or with metformin 850mg bid throughout menstrual cycle. Three
dimensional (3D) ultrasound with power Doppler examination was done on day 2 after
human chorionic gonadotropin (hCG) injection for both groups and; endometrial volume,
vascularization index (VI), flow index (FI), and vascularization flow index (VFI) of endometrial and subendometrial regions were measured.
Results: Patients taking metformin, and those destined to be pregnant had significantly
lower VI/FI/VFI in endometrial region. Corresponding decreases of values in subendometrial region were insignificant. Serum estradiol (E2) levels on day of hCG injection
were significantly lower in cycles, where metformin was added.
Conclusion: Metformin had significantly lowered VI/FI/VFI in early luteal phase in
PCOS affected women.
Keywords
Key Words: Uterine Receptivity; Three Dimensional Ultrasound; Power Doppler; Polycystic Ovary Syndrome; Clomiphene Citrate; Metformin
Statistics
Article View: 47
PDF Download: 33