A Prospective, Randomized, Comparative Clinical Study of the efficacy of Letrozole and Clomiphene Citrate as adjuvants to Follicle-Stimulating hormone in Superovulation | ||||
| The Egyptian Journal of Fertility of Sterility | ||||
| Article 4, Volume 16, Issue 1 - Serial Number 11106352, January 2012, Page 13-16 PDF (1.43 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/egyfs.2012.257280 | ||||
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| Author | ||||
| Osama A. El.Kelani, Zakaria F. Sanad | ||||
| Obstetrics and Gynecology Department , Menofiya University, Egypt | ||||
| Abstract | ||||
| Objective: To compare the efficacy of the aromatase inhibitor letrozole and clomiphene citrate (CC) as adjuvants to follicle-stimulating hormone (FSH) in superovulation. Materials & Methods: A total of 120 patients with unexplained or mild male factor infertility were randomized to receive either letrozole or CC as adjuvants to FSH. From day 3 to 7 of the cycle 2.5 mg/d letrozole or 100 mg/d CC were administered followed by 75 IU/d FSH starting on day 7 until the day of human chorionic gonadotropin (hCG). Ovulation was triggered with 10,000 IU of hCG when the leading follicle (s) reached 18 mm in diameter. A single intrauterine insemination (IUI) was performed 36 h later. Ovarian (estradiol (E2) levels and number of follicles) and endometrial (endometrial thickness) response and pregnancy outcome were the main measures. Results: The number of mature preovulatory follicles (1.9 + 0.7 vs. 2.2 + 0.5, P<0.0001) and the peak E2 level (791 + 163 vs. 1137 + 192 pg/ml, P<0.0001) were significantly higher in the CC group than in the letrozole group. A significantly higher endometrial thickness was observed on the day of hCG in the letrozole group (9.1 + 1.2 vs. 7.7 + 1.4 mm, P<0.0001). There was no significant difference between groups in clinical pregnancy rates (38.4% in the letrozole and 31.3% in the CC groups). Conclusions: The aromatase inhibitor letrozole appears to be a good alternative to CC in superovulation therapy. | ||||
| Keywords | ||||
| Key Words: Aromatase inhibitor; letrozole; clomiphene citrate; FSH; superovulation | ||||
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