AMELIORATING EFFECT OF CARICA PAPAYA L. FRUIT EXTRACT ON ENTAMOEBA HISTOLYTICA IN MICE
SAMY EL SAYED, M., MAHANA, N., RABEA, I., NIGM, A., MOSTAFA, O., ASHOUR, A. (2022). AMELIORATING EFFECT OF CARICA PAPAYA L. FRUIT EXTRACT ON ENTAMOEBA HISTOLYTICA IN MICE. EKB Journal Management System, 52(2), 215-230. doi: 10.21608/jesp.2022.257334
MENNAT-ALLAH SAMY EL SAYED; NOHA AHMED MAHANA; IBRAHIM ALI RABEA; AHMED MOHAMMAD HAMDY NIGM; OSAMA MOHAMMAD SAYED MOSTAFA; AMEEN ABD EL-BAQI ASHOUR. "AMELIORATING EFFECT OF CARICA PAPAYA L. FRUIT EXTRACT ON ENTAMOEBA HISTOLYTICA IN MICE". EKB Journal Management System, 52, 2, 2022, 215-230. doi: 10.21608/jesp.2022.257334
SAMY EL SAYED, M., MAHANA, N., RABEA, I., NIGM, A., MOSTAFA, O., ASHOUR, A. (2022). 'AMELIORATING EFFECT OF CARICA PAPAYA L. FRUIT EXTRACT ON ENTAMOEBA HISTOLYTICA IN MICE', EKB Journal Management System, 52(2), pp. 215-230. doi: 10.21608/jesp.2022.257334
SAMY EL SAYED, M., MAHANA, N., RABEA, I., NIGM, A., MOSTAFA, O., ASHOUR, A. AMELIORATING EFFECT OF CARICA PAPAYA L. FRUIT EXTRACT ON ENTAMOEBA HISTOLYTICA IN MICE. EKB Journal Management System, 2022; 52(2): 215-230. doi: 10.21608/jesp.2022.257334

AMELIORATING EFFECT OF CARICA PAPAYA L. FRUIT EXTRACT ON ENTAMOEBA HISTOLYTICA IN MICE

Journal of the Egyptian Society of Parasitology
Volume 52, Issue 2, August 2022, Page 215-230  XML PDF (1.59 MB)
DOI: 10.21608/jesp.2022.257334
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Authors
MENNAT-ALLAH SAMY EL SAYED1; NOHA AHMED MAHANA2; IBRAHIM ALI RABEA3; AHMED MOHAMMAD HAMDY NIGM1; OSAMA MOHAMMAD SAYED MOSTAFA1; AMEEN ABD EL-BAQI ASHOUR1
1Department of Zoology, Faculty of Science, Ain Shams University, Cairo 11566
2Department of Zoology, Faculty of Science, Cairo University, Giza 12613
3Parasitology Laboratory, Theodor Bilharz Research Institute (TBRI), Giza 12411
Abstract
Entamoeba histolytica is a major public health problem in tropical and subtropical countries.
Treatment failure with specific chemotherapy suggested the development of new plant origin
therapy. Different parts of Carica papaya Linn. have anti-parasitic agent. The study evaluated
the efficacy of C. papaya fruit methanolic and aqueous extracts against Entamoeba histolytica as
compared with the used Albendazole® in experimentally infected mice. Male CD-1 mice were
divided into two groups of 50 each; immunocompetent (IC) and dexamethasone immunosuppressed
(IS). Each group was subdivided into 5 subgroups, normal, infected and infected treated
with crude & pure C. papaya extracts (500mg/kg) or albendazole (200mg/kg). Each mouse was
infected orally with 1000 E. histolytica cysts. Six weeks after infection, treatment with pure and
crude extracts (3doses/ week) for 3 weeks which started from the 3rd week after oral administration
of dexamethasone, significantly reduced the trophozoites (78.20% & 76.29%, respectively)
in IC mice compared to albendazole (88.72% & 81.81%). Serum IgG, IgM, IgA antibody levels
and IFN-γ significantly (P< 0.001) increased in treated mice compared to normal ones. Histopathological
results showed improvement in the hepatic and intestinal architecture of infected
mice treated with papaya extracts and albendazole with various degrees. Results of IS groups
were the same as those of IC ones but, with lower levels.
Keywords
Entamoeba histolytica; Carica papaya; Mice; Immune responses; Polyclonal antibody; ELISA
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