Hepatitis C Positive Patients in Relation to Polyclonal and Monoclonal Gammopathy: An Egyptian Experience | ||||
| The Medical Journal of Cairo University | ||||
| Volume 90, Issue 6, June 2022, Page 1225-1230 PDF (307.09 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjcu.2022.257441 | ||||
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| Authors | ||||
| MOHAMED A.R. MOSTAFA, M.Sc.; TAHER M.H. EL ZANATY, M.D.; AYMEN M.R. FODA, M.D.; NEHAD M. TAWFIK, M.D. | ||||
| The Department of Internal Medicine, Faculty of Medicine, Misr University for Science and Technology* and Department of Internal Medicine & Gastroenterology, Faculty of Medicine, Cairo University** | ||||
| Abstract | ||||
| Abstract Background: Gammapathies is one of long term compli-cation of chronic HCV Infection B-cell lymphoproliferative diseases produced by a clonal proliferation of plasma cells producing a unique immunoglobulin are known as monoclonal gammopathies. Their clinical spectrum includes monoclonal gammopathy of undetermined significance (MGUS) and overt multiple myeloma. Aim of Study: The present study aimed to examine the prevalence, characteristics, and predictors of gammopathies in Egyptian patients with chronic HCV infection. Patients and Methods: This study conducted a prospective cohort study on patients with bilateral baggy lower eyelids who underwent traditional lower blepharoplasty with fat excision or fat-sparing technique using the orbital septal plication method. Results: The study was performed on 40 patients (20 patients per group). The right medial OGS showed a significant reduction in the fat-sparing and traditional groups (p<0.001, each). However, the percentage of reduction was significantly higher in the fat-sparing group (35.8±2.8 versus 14.6±3.4 in the traditional groups; p<0.001). Likewise, the left medial OGS showed a significant reduction in the fat-sparing and traditional groups (p<0.001, each). The percentage of reduction was significantly higher in the fat-sparing group (35.9±2.9 versus 14.7±3.3 in the traditional groups; p<0.001). Both left and right-sided central and lateral OGS showed a significant reduction in the fat-sparing and traditional groups (p<0.001, each). However, the percentage of reduction was significantly higher in the fat-sparing group (p<0.001, each). Conclusion: In conclusion, the prevalence of polyclonal gammopathy was higher in patients with chronic HCV com-pared with monoclonal, which is reported to be related to old age. Patients with gammopathy were associated with anemia, altered coagulation profile, high alfa-fetoprotein, low albumin level, and leukocytosis. Enlarged spleen, male gender, WBCS <5.000cc/mm3, and platelets below 120.000 are significant predictors of gammopathy in patients with chronic HCV. | ||||
| Keywords | ||||
| Chronic HCV; Gammopathies; Egypt; Poly-clonal gammopathy | ||||
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