COMPARATIVE STUDY BETWEEN THE EFFECTS OF METFORMIN MONOTHERAPY IN OBESE AND NON-OBESE PATIENTS WITH POLYCYSTIC OVARY SYNDROME | ||||
| The Egyptian Journal of Fertility of Sterility | ||||
| Article 2, Volume 17, Issue 2 - Serial Number 11106352, June 2013, Page 5-11 PDF (2.07 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/egyfs.2013.257473 | ||||
 View on SCiNiTO | ||||
| Author | ||||
| Ayman Nady Abdelmeged | ||||
| Department of Obstetrics and Gynecology and Minia Infertility Research Unit, Minia University, Egypt. | ||||
| Abstract | ||||
| Objective: To compare the efficacy of metformin montherapy in improvement of the clinical and biochemical parameters, ovulation and pregnancy rates in obese and non obese patients with polycystic ovary syndrome. Patients and method:We examined 110 PCOS and 36 controls aged 19- 34 years old, body mass index (BMI), A prospective comparative study in Minia University infertility clinic. One hundered infertile women were diagnosed as clomiphene citrate resistant polycystic ovary syndrome at the period starting from November 2009 to August 2010.. The patients were divided into 2 groups .Group (O); included 50 patients with BMI ≥30 kg/ m2. Group( N); included 50 patients with BMI ≤30 kg/m2. Both groups received metformin 850 mg tablet twice daily for 12 weeks. The primary outcomes were the ovulation rate, the degree of menstrual regularity , the change of the patients’ clinical and biochemical profile after three months of metformin treatment; including the changes in LH/FSH ratio.The secondary outcome was the pregnancy rate. Results:There was a statistically significant improvement as regards preand post-treatment concerning regularity of the cycle (p < 0.0001) , acne (p < 0.001) and LH: FSH ratio (p= 0.015) and no statistically significant improvement as regard hirustism between both groups .In addition,there was a statistically significant improvement as regards pre- and post-treatment concerning regularity of the cycle (p=0.0001 & 0.0002) , acne (p=0,028 & 0.033) and LH:FSH ratio(p=0.038 & 0.495 ) and no statistically significant decrease as regard hirustism in both groups. However, there were no statistically significant differences between the two groups concerning the ovulation and pregnancy rates after treatment. Conclusion:Metformin alone may be an effective drug for restoration of menstrual irregularities, LH: FSH ratio, treatment of acne, inducing ovulation and increase pregnancy rates in clomiphene citrate resistant polycystic ovary syndrome. Non obese patients responded better but statistically non significant than obese patients. Further randomized controlled studies on large number of patients are required to compare efficacy of metformin in obese and non obese PCOS patients. | ||||
| Keywords | ||||
| Key Words: Metformin; Polycystic ovary syndrome; Obesity | ||||
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