COMBINED COENZYME Q10 AS AN ADJUVANT FOR OVULATION INDUCTION IN POLYCYSTIC OVARY SYNDROME | ||||
| The Egyptian Journal of Fertility of Sterility | ||||
| Article 3, Volume 17, Issue 2 - Serial Number 11106352, June 2013, Page 12-15 PDF (1.29 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/egyfs.2013.257474 | ||||
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| Author | ||||
| Abdelaziz A. Elrefaeey, Anas M. Gama, Iman Yassein, Khaled R. Zalata1, 2 | ||||
| 11Department of Obstetrics and Gynecology | ||||
| 22Department of Pathology, Faculty of Medicine, Mansoura University, Egypt | ||||
| Abstract | ||||
| Objective: To evaluate the effect of combination of oral Coenzyme Q10 (CoQ10), with clomiphene citrate (CC) for ovulation induction in CC-resistant polycystic ovary syndrome (PCOS). Patients and method:A prospective controlled randomized trial which comprised of 110 infertile women with PCOS resistant to CC. Patients were randomized to either combined CC/CoQ10 (51 patients, 82 cycles) or CC 150 mg/day alone (50 patients, 71 cycles) for ovulation induction in patients with CC-resistant PCOS. The main outcome measures were number of follicles, serum E2, serum P, endometrial thickness, and pregnancy rate (PR) and miscarriage rate. Results:Combination of CC and coenzyme Q10 significantly increased both ovulation (p < 0.001) and pregnancy rates (p < 0.001) in women with CC-resistant PCOS compared with CC only, (65.9% vs.15.5% and 39.2% vs. 6%, respectively). No women reported side effects. Conclusion:Combination of CoQ10-CC in the treatment of CC-resistant PCOS patients improves the ovulation and pregnancy rates. It is an effective, safe option and should be considered before gonadotropin therapy or laparoscopic ovarian drilling. | ||||
| Keywords | ||||
| Key Words: Coenzyme Q10; polycystic ovary syndrome; clomiphene-citrate resistance; pregnancy | ||||
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