FIRST-TRIMESTER SERUM URIC ACID CONCENTRATIONS AS A PREDICTOR FOR GESTATIONAL DIABETES MELLITUS | ||||
| The Egyptian Journal of Fertility of Sterility | ||||
| Article 4, Volume 17, Issue 2 - Serial Number 11106352, June 2013, Page 16-21 PDF (1.6 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/egyfs.2013.257475 | ||||
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| Author | ||||
| Amr S. Khodair, Zakia M. Ibrahim, Salma E. Mohamed | ||||
| Department of Obstetrics and Gynecology, Faculty of Medicine, Suez Canal University, Suez General Hospital | ||||
| Abstract | ||||
| Objective: To evaluate first trimester serum uric acid level as a predictor for gestational diabetes mellitus. Patients and method:A prospective observational study at obstetrics and Gynecology Department of Suez Canal University Hospital during the period from March 2011 to March 2012. A total of 850 pregnant women with gestational age 10 – 13 weeks at presentation were recruited into the study. All women were subjected to complete history, full general and obstetric examination and routine obstetric ultrasonography evaluation. Serum uric acid was measured at time of presentation screening for diabetes was done at 24 - 28 weeks of gestation using 50gm oral glucose-loading test if >140mg/dl, subsequent 3hrs oral 100g glucose tolerance test (OGTT) was done, diagnosis of GDM was done when at least two of the following plasma glucose values was high. Results:A total of 37 /813women were diagnosed to have GDM. Women with GDM have higher mean BMI (29.02 kg/m2) than women without GDM (26.04 kg/m2) with p-value < 0.05. Median serum uric acid at 10 - 13 weeks of gestation was significantly higher among women with GDM (3.5 mg/dl versus 2.9 mg/dl among women without GDM, p-value < 0.05). The adjusted odds of gestational diabetes increased with increasing first trimester uric acid quartile (p=0.003 for trend). ROC curve showed that best cutoff value was set at ≥ 3.05mg/dl with 75.7% sensitivity, 57.8% specificity, 7.5% positive predictive value and 89.1% negative predictive value. Risk estimate showed increased risk of GDM with serum uric acid ≥ 3.05 mg/dl with risk ratio =4.02. Conclusion: first trimester serum uric acid concentration is a significant predictor for development of GDM. | ||||
| Keywords | ||||
| Keywords: Uric acid; Gestational Diabetes Mellitus; Hyperuricemia | ||||
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