Improving the pregnancy rates by pre-ovulatory saline perturbation before intrauterine insemination: A prospective randomized controlled trial | ||||
| The Egyptian Journal of Fertility of Sterility | ||||
| Article 4, Volume 19, Issue 1 - Serial Number 11106352, January 2015, Page 23-27 PDF (1.52 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/egyfs.2015.257489 | ||||
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| Author | ||||
| Moustafa Al Khiary El Zayat M | ||||
| Assistant professor of OB/GYN, Mansoura University | ||||
| Abstract | ||||
| Objective: to evaluate effect of pre ovulatory saline flushing on pregnancy rate in patients with ovulatory dysfunction, unexplained infertility, endometriosis and male sub-fertility. Patients & Methods: the study involved 246 of infertile couples divided blindly by election into two equal groupseach contain 123; non pertubated group (A) and saline infusion group (B). Controlledovarian hyper-stimulation by Clomiphene Citrate (100 mg on cycle day 3-7) +HMG (75-150 IU) followed by administration of HCG 5000 IU IM. On the pre-ovulatory day; when one or two follicles >17mm by TVS, tubal flushing with 20 ml salinewas carried out in half of the cases (group B). Results: Patient’s demographic data in both groups showed no significant differences, the mean age was 27.8 ± 7.3 and 26.7 ± 8.1 years respectively. The mean weight in Kg ± SD was 77.1 ± 9.9 and 79.8 ± 10.3, the mean height in cm ± SD was 160.5 ± 5.8 and 162.8 ± 7.1 while the duration of infertility in years was 3.4 ± 1.6 and 3.5 ± 1.1 years respectively. The number of follicles reached the maturity in both groups showed no significant difference being 4.43 ± 1.7 and 4.67 ±1 respectively while the overall pregnancy rate was significantly different in both groups (15/123 =12.1% in group A and 29/123 =23.57 % in group B and p-value < 0.001). Abnormal pregnancies were more or less similar in both groups (multiple pregnancy, abortion and ectopic occurred in 4,2 and 1 case of the first while occurred in 5,4 and 1 case of the second group). Finally the live birth rates was 7.3 % (9/123) in group A and 19.5 % (24/123) with a significant difference (p value < 0.005). Conclusion: adding saline flushing to (COH +IUI) cycles can be used as a cost-effective first line treatment for couples with infertility. | ||||
| Keywords | ||||
| Key Words: tubal hydrotubation; infertility; IUI | ||||
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