Diagnostic utility of absolute neutrophil count as a new marker of spontaneous bacterial peritonitis; multicenter study | ||||
Medical Journal of Viral Hepatitis | ||||
Article 2, Volume 6.3, Issue 3, August 2022, Page 12-18 PDF (253.76 K) | ||||
Document Type: Original article | ||||
DOI: 10.21608/mjvh.2022.257546 | ||||
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Authors | ||||
Tarek Sheta 1; Ahmed El-mesery2; Kamal Salama3; Niveen El-Wakeel4; Ola El-Emam5; Alaaudin Habib1 | ||||
1Internal Medicine Department, Mansoura University, Mansoura Egypt | ||||
2Tropical Medicine Department, Mansoura University, Mansoura, Egypt | ||||
3Damietta Cardiology and Gastroenterology Center, Damietta, Egypt | ||||
4Medical Microbiology and Immunology, Mansoura University, Mansoura, Egypt | ||||
5Clinical Pathology Department, Mansoura university, Egypt | ||||
Abstract | ||||
Background: Spontaneous bacterial peritonitis (SBP) is a fatal complication of liver cirrhosis with high mortality rates. The aim of this study is to investigate the diagnostic utility of absolute neutrophil count (ANC) as a non-invasive marker for SBP diagnosis. Methods: Six hundred patients with cirrhotic ascites were included in the study. All patients underwent abdominal paracentesis and the ascitic fluid was processed for cell count and culture. Results: Absolute neutrophil count was significantly higher in SBP versus non-SBP and in culture positive SBP versus culture negative SBP. ANC at cutoff value > 2.804 has 84% sensitivity and 78% specificity for diagnosis of SBP with positive and negative predictive values (79.4% and 83.6 respectively). At a cut-off point > 5.6, ANC is capable of differentiating culture positive SBP from culture negative SBP cases with 62.07% sensitivity and 60.87 % specificity. Increased ANC, white blood cell (WBC), C reactive protein (CRP), creatinine and decreased platelet emerged as independent risk factors for SBP development, while increased ANC, WBC and decreased platelets were independent predictors of culture positive SBP. Conclusion: This study demonstrates that, ANC count is simple, non-invasive diagnostic marker for SBP. Increased ANC, WBC, CRP, creatinine and decreased platelet emerged as independent risk factors for SBP development. | ||||
Keywords | ||||
Ascites; spontaneous bacterial peritonitis; absolute neutrophil count; C reactive protein; bacterial peritonitis; and liver cirrhosis | ||||
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