in silico Design, and in vivo evaluation of synthesized phenyl isoserine derivative and used as anticytokine storm.
sabbar omran, Z., Bahaa Sahib, H., Radhi, A., Ali, N. (2023). in silico Design, and in vivo evaluation of synthesized phenyl isoserine derivative and used as anticytokine storm.. EKB Journal Management System, 66(5), 151-159. doi: 10.21608/ejchem.2022.144346.6319
zahraa sabbar omran; Hayder Bahaa Sahib; Ali Jabbar Radhi; Noor Ali. "in silico Design, and in vivo evaluation of synthesized phenyl isoserine derivative and used as anticytokine storm.". EKB Journal Management System, 66, 5, 2023, 151-159. doi: 10.21608/ejchem.2022.144346.6319
sabbar omran, Z., Bahaa Sahib, H., Radhi, A., Ali, N. (2023). 'in silico Design, and in vivo evaluation of synthesized phenyl isoserine derivative and used as anticytokine storm.', EKB Journal Management System, 66(5), pp. 151-159. doi: 10.21608/ejchem.2022.144346.6319
sabbar omran, Z., Bahaa Sahib, H., Radhi, A., Ali, N. in silico Design, and in vivo evaluation of synthesized phenyl isoserine derivative and used as anticytokine storm.. EKB Journal Management System, 2023; 66(5): 151-159. doi: 10.21608/ejchem.2022.144346.6319

in silico Design, and in vivo evaluation of synthesized phenyl isoserine derivative and used as anticytokine storm.

Egyptian Journal of Chemistry
Volume 66, Issue 5, May 2023, Page 151-159  XML PDF (672.91 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2022.144346.6319
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Authors
zahraa sabbar omran email 1; Hayder Bahaa Sahib2; Ali Jabbar Radhi3; Noor Ali4
1ahlalbyte university
2College of Pharmacy, Al-Nahrain University, Baghdad, Iraq
3Faculty of Pharmacy, Al-Kafeel University, Najaf, Iraq.
4Department of Chemistry and Biochemistry /College of Medicine /AL-Nahrain University/ Baghdad/Iraq
Abstract
Abstract:
Cytokine storm is several disorders of immune dysregulation characterized by constitutional symptoms, systemic inflammation, and multiorgan dysfunction that can lead to multiorgan failure if inadequately treated, 1,2,3-Triazoles are one of the most important nitrogen-containing five-membered heterocycles and have a wide range of applications in pharmaceuticals, supramolecular chemistry, organic synthesis, chemical biology and industry.In the current work , the synthesized compounds (1d and 2d) were screened for their anticytokine storm by assay of IL-1b and IL-6 in vivo, confirmations and characterization of the chemical structures related to these compounds were performed using 1H-NMR spectroscopy, FT-IR spectroscopy, and some physicochemical properties such as melting points. Docking study of the final synthesized compounds gave evidence about the affinity of these compounds significantly inhibited IL in comparison to positive groups
Keywords
Keywords: Anti-cytokine storm; N-benzyle phenylisoserine; molecular docking 1,2,3-Triazoles
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