Studies on Synthesis, Characterization and Biological Activities of Novel Schiff Bases from amino acridone | ||||
| Egyptian Journal of Chemistry | ||||
| Article 24, Volume 66, Issue 6, June 2023, Page 225-234 PDF (802.52 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2022.155588.6713 | ||||
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| Authors | ||||
Maryam Fawzi Habeeb1; Attalla M. Sheat 2
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| 1Department of Chemistry ,College of Science ,University of Mosul, Iraq. | ||||
| 2Department of Chemistry ,College of Science ,University of Mosul, Iraq | ||||
| Abstract | ||||
| Abstract Ullmann reaction was used to synthesis the N-anthranilic acid by reaction of o-chloro benzoic acid derivatives with o- and p-phenylene diamine, then the compounds were cyclized to amino acridone derivatives using poly(phosphoric acid) (PPA). Terphthaldehyde mono Schiff bases were synthesized by reaction 1:1mole of one of the following ( o-,m-,p-toluidine and p-anisidine) with Terphthaldehyde. Extra Schiff bases were synthesized by reaction of previous prepared amino acridone derivatives with mono Schiff bases of Terphthaldehyde . In addition, other compounds were synthesized by reaction of aforesaid amino acridone derivatives each with 1 mole of Terphthaldehyde, 4-(dimethyl amino)benzaldehyde, 2-formyl benzoic acid and methyl-4-formyl benzoate. All synthesized compounds were characterized by FTIR,1H NMR and 13C NMR spectroscopy. Some of the new synthesized products were examin their antibacterial activities against [Escherichia coli , Klepsiella pneumoniae ,Staphlococcus aurous, Pseudomonas aeroginosa] . | ||||
| Keywords | ||||
| Keywords: Ullmann reaction; amino acridone derivatives; Schiff bases; terphthaldehyde; N-anthanilic acid; biological activities | ||||
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