Autologous Platelet Rich Plasma versus Autologous Serum Eye Drops in Treatment of Severe Dry Eye Disease | ||||
| International Journal of Medical Arts | ||||
| Article 1, Volume 4, Issue 8, August 2022, Page 2542-2549 PDF (1.64 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ijma.2022.152958.1490 | ||||
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| Authors | ||||
Esraa Abobakr Mohammad  1; Nashwa Mohammad Lamie1; Amira Nasr Ismail2; Mona Nabeh Mansour1
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| 1Department of Ophthalmology, Faculty of Medicine [for Girls], Al-Azhar University, Cairo, Egypt | ||||
| 2Department of Histopathology, Faculty of Medicine [for Girls], Al-Azhar University, Cairo, Egypt | ||||
| Abstract | ||||
| Background: Dry eye disease [DED] results in symptoms of discomfort, visual disturbance, and tear film instability with potential damage to the ocular surface. Biological tear substitutes, a blood derivative, demonstrated good efficacy in improvement of symptoms and ocular surface staining reduction in patients with moderate-to-severe dry eye disease. Aim of the work: To evaluate the efficacy of autologous serum [AS] eye drops [20%], platelet rich plasma [PRP] eye drops [20%], for treatment of severe DED and comparing their results with each other. Patients and methods: A prospective comparative study included 120 eyes of 60 patients with severe DED aged 18 - 67 years. Patients divided into 2 groups according to treatment protocol: Group I: 60 eyes of 30 patients treated with autologous serum eye drops, Group II: 60 eyes of 30 patients treated with autologous platelet rich plasma eye drops. They underwent a comprehensive ophthalmic examination, evaluation of best corrected visual acuity [BCVA], tear break-up time [TBUT], Schirmer’s test, corneal fluorescein staining [CFS; oxford grading scale], and level of Conjunctival hyperaemia [Efron grading scale] during 6 weeks of treatment. Conjunctival impression cytology [CIC] studied before and after treatment. Results: Statistically significant larger improvement in BUT [p=0.001], Schirmer’s test [p < 0.001] and significantly larger reduction of CFS [p < 0.001] in Group II compared to Group I at six weeks after treatment. Likewise, a significant improvement of Nelson grading of CIC [p =0.04] was found in Group II. Greater reduction of conjunctival hyperaemia but not statistically significant [p = 0.275], also the improvement in BCVA [log MAR], [p=0.242], in Group II compared to Group I at six weeks after treatment. Conclusion: PRP eye drops induces a more significant improvement in different DED signs than AS in treatment of severe dry eye disease. | ||||
| Keywords | ||||
| Dry eye; Autologous serum; Platelet rich plasma; Tear break-up time; Schirmer’s test; Corneal Fluorescein staining; Conjunctival hyperaemia; Conjunctival impression cytology | ||||
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