Synthesis, characterization, potential anticancer activity, and molecular docking studies of Fe(II)Prolinedithiocarbamate complex on MCF-7 breast cancer cell lines
Jarre, S., Raya, I., Prihantono, P., Arfah, R., Gappa, M., Fauziah, S., Santi, S., Irfandi, R. (2023). Synthesis, characterization, potential anticancer activity, and molecular docking studies of Fe(II)Prolinedithiocarbamate complex on MCF-7 breast cancer cell lines. EKB Journal Management System, 66(6), 61-67. doi: 10.21608/ejchem.2022.149508.6466
Sulistiani Jarre; Indah Raya; Prihantono Prihantono; Rugaiyah Arfah; Maming Gappa; Siti Fauziah; Santi Santi; Rizal Irfandi. "Synthesis, characterization, potential anticancer activity, and molecular docking studies of Fe(II)Prolinedithiocarbamate complex on MCF-7 breast cancer cell lines". EKB Journal Management System, 66, 6, 2023, 61-67. doi: 10.21608/ejchem.2022.149508.6466
Jarre, S., Raya, I., Prihantono, P., Arfah, R., Gappa, M., Fauziah, S., Santi, S., Irfandi, R. (2023). 'Synthesis, characterization, potential anticancer activity, and molecular docking studies of Fe(II)Prolinedithiocarbamate complex on MCF-7 breast cancer cell lines', EKB Journal Management System, 66(6), pp. 61-67. doi: 10.21608/ejchem.2022.149508.6466
Jarre, S., Raya, I., Prihantono, P., Arfah, R., Gappa, M., Fauziah, S., Santi, S., Irfandi, R. Synthesis, characterization, potential anticancer activity, and molecular docking studies of Fe(II)Prolinedithiocarbamate complex on MCF-7 breast cancer cell lines. EKB Journal Management System, 2023; 66(6): 61-67. doi: 10.21608/ejchem.2022.149508.6466

Synthesis, characterization, potential anticancer activity, and molecular docking studies of Fe(II)Prolinedithiocarbamate complex on MCF-7 breast cancer cell lines

Egyptian Journal of Chemistry
Article 6, Volume 66, Issue 6, June 2023, Page 61-67  XML PDF (499.35 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2022.149508.6466
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Authors
Sulistiani Jarre1; Indah Raya email orcid 2; Prihantono Prihantonoorcid 3; Rugaiyah Arfah4; Maming Gappa1; Siti Fauziah5; Santi Santi6; Rizal Irfandiorcid 7
1Department of Chemistry, Hasanuddin University
2Chemistry Department, Hasanuddin University
3Department of Oncology, Medicine Faculty, Hasanuddin University, Perintis Kemerdekaan Street Km. 10 Tamalanrea, Makassar 90245, Indonesia
4Departement of Chemistry, Faculty of Mathematics and Natural Sciences, Hasanuddin University, Makassar, 90245, Indonesia
5Department of Chemistry, Faculty of Mathematics and Natural Science, University of Hasanuddin, Jalan. Perintis Kemerdekaan 90245, Makassar-Indonesia
6Medical Laboratory Technology, Megarezky University
7Department of Biology Education, Faculty of Teacher Training and Education, Puangrimaggalatung University, Sengkang, Indonesia
Abstract
A new complex compound of Fe(II)Prolinedithiocarbamate has been synthesized, characterized, and was tested for MCF-7 cell in vitro and in silico with molecular docking studies. Characterized tests such as melting point, conductivity, UV-Vis spectroscopy, and FT-IR spectroscopy have been performed. The in vitro test results showed morphological changes (apoptosis) in MCF-7 cancer cells start at 75 μg/ml. The molecular docking study of the complex Fe(II)Prolinedithiocarbamate was identified with O(6)-methylguanine-DNA methyltransferase (MGMT) protein. Fe(II)Prolinedithiocarbamate - O(6)-methylguanine-DNA methyltransferase (MGMT) showed the active site with amino acid residues GLU77, LEU142, ILE76, dan TRP65. The hydrogen and hydrophobic bond were seen in Fe(II)Prolinedithiocarbamate - O(6)-methylguanine-DNA methyltransferase (MGMT) has a binding energy -183.25 kJ/mol. According in vitro test and molecular docking study, this compound has a potential anticancer activity.
Keywords
Complex; Cytotoxicity; MCF-7 cell lines; Breast Cancer; Anticancer activity; Dithiocarbamate
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