Therapeutic role of intravenous mesenchymal stem cells infusion in a rat model of induced acute myocardial infarction
El-Shetry, E., Salah Eldin Taha, A., Elgazzar, A., El-Shetry, M., Hendawy, D., Borai, E. (2024). Therapeutic role of intravenous mesenchymal stem cells infusion in a rat model of induced acute myocardial infarction. EKB Journal Management System, 30(2), 317-325. doi: 10.21608/zumj.2022.152270.2608
Eman S. El-Shetry; Adel M Salah Eldin Taha; Aya Mahmoud Elgazzar; Mohamed Saad El-Shetry; Doaa Hendawy; Eman Borai. "Therapeutic role of intravenous mesenchymal stem cells infusion in a rat model of induced acute myocardial infarction". EKB Journal Management System, 30, 2, 2024, 317-325. doi: 10.21608/zumj.2022.152270.2608
El-Shetry, E., Salah Eldin Taha, A., Elgazzar, A., El-Shetry, M., Hendawy, D., Borai, E. (2024). 'Therapeutic role of intravenous mesenchymal stem cells infusion in a rat model of induced acute myocardial infarction', EKB Journal Management System, 30(2), pp. 317-325. doi: 10.21608/zumj.2022.152270.2608
El-Shetry, E., Salah Eldin Taha, A., Elgazzar, A., El-Shetry, M., Hendawy, D., Borai, E. Therapeutic role of intravenous mesenchymal stem cells infusion in a rat model of induced acute myocardial infarction. EKB Journal Management System, 2024; 30(2): 317-325. doi: 10.21608/zumj.2022.152270.2608

Therapeutic role of intravenous mesenchymal stem cells infusion in a rat model of induced acute myocardial infarction

Zagazig University Medical Journal
Article 2, Volume 30, Issue 2, March and April 2024, Page 317-325  XML PDF (1.16 MB)
Document Type: Original Article
DOI: 10.21608/zumj.2022.152270.2608
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Authors
Eman S. El-Shetry email 1; Adel M Salah Eldin Taha1; Aya Mahmoud Elgazzar2; Mohamed Saad El-Shetryorcid 3; Doaa Hendawy4; Eman Borai1
1Department of Human Anatomy and Embryology, Faculty of Medicine, Zagazig University, Zagazig, Egypt
2Department Of Human Anatomy and Embryology, Faculty of Medicine, Zagazig, Egypt
3Cardiology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
4Department of Biochemistry, Faculty of Medicine, Zagazig University, Zagazig, Egypt
Abstract
Background: Acute Myocardial Infarction (AMI) is a well-established cause of morbidity and mortality globally in spite of recent breakthroughs in medical therapy as reperfusion methods, implantable cardioverter-defibrillators, and ventricular assist devices. In myocardial infarction treatment, bone marrow-derived mesenchymal stem cells (BM-MSCs) are expected to demonstrate encouraging results.
Objective: This study aimed to evaluate the feasible anti-inflammatory and antioxidant role of BM-MSCs infusion in rat model with induced myocardial infarction.
Material and methods: Rats were randomized into an experimental (AMI) group induced by Adrenaline injection, and a control group. The (AMI) group was divided into 2 subgroups (AMI+PBS) and (AMI+BM-MSCs). The consequences of BM-MSCs infusion on cardiac inflammation and oxidative stress status were observed after 3 days of cell transplantation.
Results: BM-MSCs transplantation reduced the production of the inflammatory cytokine (TNF-a) & oxidative stress markers (MDA), increased anti-inflammatory IL-10 & antioxidant SOD, and improved histological changes in the ischemic myocardium.
Conclusion: This study provides evidence that BM-MCSs suppress oxidative stress and inflammation in cardiac tissue and relatively offer cardiac protection in AMI
Keywords
Acute Myocardial Infarction; Mesenchyme Stem Cells; Rat Model
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