Parasitic Infections’ Immunomodulatory Effects and Autoimmune Diseases
Elsawey, A., Nabih, N., .M., G., Etewa, S., Aboulfotouh, N. (2022). Parasitic Infections’ Immunomodulatory Effects and Autoimmune Diseases. EKB Journal Management System, 14(2), 27-37. doi: 10.21608/eajbse.2022.259101
Aliaa M. Elsawey; Nairmen Nabih; Gaballah, E. .M.; Samia E. Etewa; Nora Aboulfotouh. "Parasitic Infections’ Immunomodulatory Effects and Autoimmune Diseases". EKB Journal Management System, 14, 2, 2022, 27-37. doi: 10.21608/eajbse.2022.259101
Elsawey, A., Nabih, N., .M., G., Etewa, S., Aboulfotouh, N. (2022). 'Parasitic Infections’ Immunomodulatory Effects and Autoimmune Diseases', EKB Journal Management System, 14(2), pp. 27-37. doi: 10.21608/eajbse.2022.259101
Elsawey, A., Nabih, N., .M., G., Etewa, S., Aboulfotouh, N. Parasitic Infections’ Immunomodulatory Effects and Autoimmune Diseases. EKB Journal Management System, 2022; 14(2): 27-37. doi: 10.21608/eajbse.2022.259101

Parasitic Infections’ Immunomodulatory Effects and Autoimmune Diseases

Egyptian Academic Journal of Biological Sciences, E. Medical Entomology & Parasitology
Article 4, Volume 14, Issue 2, December 2022, Page 27-37  XML PDF (500.88 K)
Document Type: Original Article
DOI: 10.21608/eajbse.2022.259101
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Authors
Aliaa M. Elsawey1; Nairmen Nabih1; Gaballah, E. .M.2; Samia E. Etewa3; Nora Aboulfotouh1
1Department of Medical Parasitology, Faculty of Medicine, Mansoura University
2Department of Medical Parasitology, Faculty of Medicine, Damietta University culty of medicine, Damietta univercity, Egypt
3Department of Medical Parasitology, Faculty of Medicine, Zagazig University
Abstract
The hygiene hypothesis has been implicated in the dramatic increase in autoimmune and allergic diseases noticed in recent decades, especially in developed countries. This growth was associated with lesser exposure to diverse immunoregulatory infectious agents. This hypothesis has been proved by many potent epidemiological and experimental studies. The results of these studies along with the analysis of the western world’s microbiome helped us to have a greater idea about microorganisms shared in the hygiene hypothesis, as well as their main mechanisms that have an effect on the immune system. Protozoal infections have been proved to have remarkable immunomodulatory changes in different autoimmune diseases. Helminths and their derivatives were proved to have a protective role. Helminths’ broad immunomodulatory effects have been tested in clinical trials of autoimmune diseases, including inflammatory bowel disease, multiple sclerosis, rheumatoid arthritis, and type-1 diabetes. In this review, we discussed particular parasitic infections and their immunomodulatory effects on some autoimmune diseases.
Keywords
Hygiene hypothesis; autoimmunity; allergy; helminths; protozoa
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