Comorbidity Index in Predicting Toxicity and Mortality Risk among patient Undergoing Hematopoietic Stem Cell Transplantation | ||||
Egyptian Journal of Health Care | ||||
Article 12, Volume 13, Issue 4, December 2022, Page 152-167 PDF (1.34 MB) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/ejhc.2022.259184 | ||||
View on SCiNiTO | ||||
Authors | ||||
Sara Abdelkader Abdelfattah1; Amany Mohamed Safwat2; Gamal El-dein Mohamed3; Dina Mohamed Maarouf4 | ||||
1Demonstrator in Critical Care Nursing, Faculty of Nursing- Ain Shams University, Egypt | ||||
2Professor in Critical Care Nursing Faculty of Nursing- Ain Shams University, Egypt | ||||
3Professor in Hematology and bone marrow transplantation Faculty of Medicine- Ain Shams University, Egypt | ||||
4Lecturer in Critical Care Nursing Faculty of Nursing- Ain Shams University, Egypt | ||||
Abstract | ||||
Background: Despite current improvement in supportive care, mortality after hematopoietic stem cell transplantation remains high. Depending on the diagnosis, this procedure is indicated as the frontline treatment Aim: Assess comorbidity index in predicting toxicity and mortality risk among patient undergoing hematopoietic stem cell transplantation through: assess comorbidities of patient’s pre-hematopoietic stem cell transplantation, assess toxicity and mortality risk post hematopoietic stem cell transplantation & assess the relation of pre-transplantation comorbidity scores and post transplantation-related toxicity and mortality in patients undergoing hematopoietic stem cell Transplantation. Study design: A descriptive retrospective design was utilized to conduct this study. Subject: A purposive sample of (44) patients undergoing allogeneic hematopoietic stem cell transplantation was recruited in this study. Setting: This study conducted at The Bone Marrow Transplantation Unit in Nasser institute for research and treatment. Tools: Tool I. Patient structured interview questionnaire, Tools II. The hematopoietic stem cell transplantation specific-comorbidity index (HCT-CI) & Tools III Seattle Criteria for Organ Toxicity after Bone Marrow Transplantation. Results: The study revealed that there was a positive Correlation between comorbidity, organ toxicity and total mortality post bone marrow transplantation with p value 0.01. Conclusion: Comorbidity index is an important tool to predict toxicity and mortality rate among patient undergoing hematopoietic stem cell transplantation as there was a positive correlation between patient’s comorbidity (obesity, cerebrovascular disease, cardiac disease, infection, renal disease, prior malignancy, hepatic disease and psychiatric disorder) and total toxicity and mortality post bone marrow transplantation. Recommendations: Apply Comorbidity Index in predicting toxicity and mortality risk among patient undergoing Hematopoietic Stem Cell Transplantation. | ||||
Keywords | ||||
Comorbidity Index; Hematopoietic Stem Cell Transplantation | ||||
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