Prostaglandin E1 Analog: Comparison between Two Different Routes of Administration for the Prevention of Post-Partum Hemorrhage | ||||
| International Journal of Medical Arts | ||||
| Article 2, Volume 4, Issue 7, July 2022, Page 2479-2484 PDF (800.4 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ijma.2022.155989.1494 | ||||
 View on SCiNiTO | ||||
| Author | ||||
Moatazza Mahdy Elghazaly 
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| Department of Obstetrics and Gynecology, Faculty of Medicine [Girls], Al-Azhar university, Cairo, Egypt | ||||
| Abstract | ||||
| Background: Postpartum hemorrhage [PPH] is considered as the major cause of maternal death worldwide. A Prostaglandin E1 analog, Misoprostol, has been demonstrated to be useful in lowering intra and postoperative blood loss. However, the proper timing of administration is still up for debate. Objective: Comparative study of Prostaglandin E1 analog [misoprostol] administration via two distinct routes: preoperative rectal and intraoperative intrauterine administration to reduce blood loss during and after cesarean delivery. Patients and Methods: This is a randomized clinical trial that involved 100 pregnant women attending Alzhraa University Hospital, all of them were eligible for elective cesarean section. All participants were randomized into two groups: Group [1]: which involved 50 women who received 400 ug misoprostol intrauterine intraoperative, and Group [2]: which involved 50 women who received 400 ug misoprostol rectally preoperative. Results: The two groups were not statistically significant different regarding the amount of blood loss or the occurrence of postpartum hemorrhage P-value [P<0.05]. The Apgar scores were considerably higher in the intrauterine Group compared to the rectal Group at both 1 and 5 minutes. Conclusion: Both preoperative rectal and intraoperative intrauterine administration of Misoprostol [400ug] have the same effect on the amount of blood loss during caesarean delivery; however, it is more convenient to be administrated during caesarean delivery with a safer neonatal outcome. | ||||
| Keywords | ||||
| Post-partum; Bleeding; Intrauterine, Rectally; Misoprostol | ||||
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