The expression of BMI-1 in ameloblastoma and dentigerous cyst | ||||
| Mansoura Journal of Dentistry | ||||
| Volume 9, Issue 3, September 2022, Page 123-127 PDF (834.79 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjd.2022.259780 | ||||
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| Abstract | ||||
| Objective: To check for a possible relation between the expression of BMI-1 among two different odontogenic lesions; ameloblastoma and dentigerous cyst known for different biological behavior. Materials and Methods: The study was conducted on 14 formalin-fixed paraffin-embedded blocks (ameloblastoma (Am) group: seven blocks and dentigerous cyst (DC) group: seven blocks). These blocks were collected from archived files of the Department of Oral Pathology, Faculty of Dentistry, Mansoura University. Immunohistochemically (IHC), the BMI-1 polyclonal antibody expression in the retrieved sections was investigated. A computerized method was used to compare the IHC staining intensity between both groups. Results: The difference in the intensity of immunoreactivity to BMI-1 in two different studied groups was statistically non-significant to gender, age, and site (P > 0.05). The Am group showed significantly higher expression of BMI-1 than the DC group (P < 0.0001). Conclusions: BMI-1 is thought of as a useful marker probably delineating the variation in the biological behavior of Am and DC. | ||||
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