Histological criteria of hippocampus as affected by acrylamide and the possible protective potential of saffron
Nassar, S., Mohammed, A., Algazeery, A. (2022). Histological criteria of hippocampus as affected by acrylamide and the possible protective potential of saffron. EKB Journal Management System, 2022(2), 37-46. doi: 10.21608/bfszu.2022.128670.1119
Samir Abd El Azeem Nassar; Abdelrahman Saied Mohammed; Ahmed A. Algazeery. "Histological criteria of hippocampus as affected by acrylamide and the possible protective potential of saffron". EKB Journal Management System, 2022, 2, 2022, 37-46. doi: 10.21608/bfszu.2022.128670.1119
Nassar, S., Mohammed, A., Algazeery, A. (2022). 'Histological criteria of hippocampus as affected by acrylamide and the possible protective potential of saffron', EKB Journal Management System, 2022(2), pp. 37-46. doi: 10.21608/bfszu.2022.128670.1119
Nassar, S., Mohammed, A., Algazeery, A. Histological criteria of hippocampus as affected by acrylamide and the possible protective potential of saffron. EKB Journal Management System, 2022; 2022(2): 37-46. doi: 10.21608/bfszu.2022.128670.1119

Histological criteria of hippocampus as affected by acrylamide and the possible protective potential of saffron

Bulletin of Faculty of Science, Zagazig University
Article 4, Volume 2022, Issue 2, July 2022, Page 37-46  XML PDF (1.29 MB)
Document Type: Original Article
DOI: 10.21608/bfszu.2022.128670.1119
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Authors
Samir Abd El Azeem Nassar email 1; Abdelrahman Saied Mohammed2; Ahmed A. Algazeery3
1Zoology Department, Faculty of Science, Zagazig university
2Zoology Department, Faculty of Science, Zagazig University, Zagazig, Egypt
3Zoology Department, Faculty of Science, Zagazig University
Abstract
Acrylamide (ACR) became an environmental pollutant due to huge and progressive exposure for both experimental animals and humans. Alternative medicine research paid more attention to natural antioxidants. Saffron exhibited obvious antioxidant and medically-beneficial properties. Here, the present study aimed to investigate the possible neuro-protective effect of saffron against acrylamide-induced histopathological alterations in hippocampal tissue of albino rats. Adult male albino rats were categorized equally into 4 groups (n = 8); control, saffron, ACR and ACR + saffron groups. Our results recorded histopathological changes due to exposure of rats to ACR toxicity in hippocampus. The pyramidal cells of Ammon’s horn (CA1- CA4) appeared degenerated and necrotic with hemorrhage, decreased thickness and increased vacuolization concomitant to shrinkage and damage of these neurons. The dentate gyrus, in its turn, appeared more affected by ACR exposure of experimental animals at the cellular level where darkly-stained and degenerated granular cells with vacuolization could be detected. Conclusion; the present study confirmed ACR-induced neurotoxicity in rats (50 mg/kg) and suggested the use of saffron extract (80 mg/kg) to prevent or delay neurological damages induced by ACR exposure.
Keywords
Acrylamide; Neurotoxicity; hippocampus; Saffron; histopathology
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