Effect of calcium hypochlorite as a source of hypochlorous acid in ameliorating cyclophosphamide-induced pulmonary and cardiac injury in mice
Akl, M., Nazmy, E., El-Khouly, O. (2022). Effect of calcium hypochlorite as a source of hypochlorous acid in ameliorating cyclophosphamide-induced pulmonary and cardiac injury in mice. EKB Journal Management System, 8(3), 212-220. doi: 10.21608/jbaar.2022.259963
Maher M. Akl; Entsar A. Nazmy; Omar A. El-Khouly. "Effect of calcium hypochlorite as a source of hypochlorous acid in ameliorating cyclophosphamide-induced pulmonary and cardiac injury in mice". EKB Journal Management System, 8, 3, 2022, 212-220. doi: 10.21608/jbaar.2022.259963
Akl, M., Nazmy, E., El-Khouly, O. (2022). 'Effect of calcium hypochlorite as a source of hypochlorous acid in ameliorating cyclophosphamide-induced pulmonary and cardiac injury in mice', EKB Journal Management System, 8(3), pp. 212-220. doi: 10.21608/jbaar.2022.259963
Akl, M., Nazmy, E., El-Khouly, O. Effect of calcium hypochlorite as a source of hypochlorous acid in ameliorating cyclophosphamide-induced pulmonary and cardiac injury in mice. EKB Journal Management System, 2022; 8(3): 212-220. doi: 10.21608/jbaar.2022.259963

Effect of calcium hypochlorite as a source of hypochlorous acid in ameliorating cyclophosphamide-induced pulmonary and cardiac injury in mice

Journal of Bioscience and Applied Research
Volume 8, Issue 3, September 2022, Page 212-220  XML PDF (1.37 MB)
Document Type: Original Article
DOI: 10.21608/jbaar.2022.259963
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Authors
Maher M. Akl1; Entsar A. Nazmy2; Omar A. El-Khouly email 3
1Faculty of Science, Mansoura University, 35516, Mansoura, Egypt
2Critical Care and Emergency Department, Kafr ElSheikh Directorate of Health, Ministry of Health and Population, Egypt
3Faculty of Pharmacy, New Mansoura University, New Mansoura, Egypt.
Abstract
Acute respiratory distress syndrome (ARDS) is recognized to be accompanied by severe lung and heart complications. This study aimed to demonstrate the efficacy of Calcium hypochlorite in cyclophosphamide (CP)-induced pulmonary and cardiac injury in mice. The CP-induced toxicity in the lung and heart is like that caused by ARDS. Calcium hypochlorite significantly attenuated doth lung and heart functionality and significantly reduced the CP-induced perivascular inflammation, congestion of blood vessels, and severe morphological changes of the alveolar wall. It also exerts anti-inflammatory and antioxidant effects on CP-induced pulmonary and heart toxicity. Given these results, calcium hypochlorite successfully ameliorates ARDS symptoms rendering calcium hypochlorite to be a promising agent to be tested in models of pneumonia caused by bacterial or viral infections, including those of acute respiratory distress syndrome (ARDS).
Keywords
Acute respiratory distress syndrome (ARDS); hypochlorous acid (HOCl); inflammatory response; oxidative stress biomarkers
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