Effect of calcium hypochlorite as a source of hypochlorous acid in ameliorating cyclophosphamide-induced pulmonary and cardiac injury in mice | ||||
Journal of Bioscience and Applied Research | ||||
Volume 8, Issue 3, September 2022, Page 212-220 PDF (1.37 MB) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/jbaar.2022.259963 | ||||
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Authors | ||||
Maher M. Akl1; Entsar A. Nazmy2; Omar A. El-Khouly 3 | ||||
1Faculty of Science, Mansoura University, 35516, Mansoura, Egypt | ||||
2Critical Care and Emergency Department, Kafr ElSheikh Directorate of Health, Ministry of Health and Population, Egypt | ||||
3Faculty of Pharmacy, New Mansoura University, New Mansoura, Egypt. | ||||
Abstract | ||||
Acute respiratory distress syndrome (ARDS) is recognized to be accompanied by severe lung and heart complications. This study aimed to demonstrate the efficacy of Calcium hypochlorite in cyclophosphamide (CP)-induced pulmonary and cardiac injury in mice. The CP-induced toxicity in the lung and heart is like that caused by ARDS. Calcium hypochlorite significantly attenuated doth lung and heart functionality and significantly reduced the CP-induced perivascular inflammation, congestion of blood vessels, and severe morphological changes of the alveolar wall. It also exerts anti-inflammatory and antioxidant effects on CP-induced pulmonary and heart toxicity. Given these results, calcium hypochlorite successfully ameliorates ARDS symptoms rendering calcium hypochlorite to be a promising agent to be tested in models of pneumonia caused by bacterial or viral infections, including those of acute respiratory distress syndrome (ARDS). | ||||
Keywords | ||||
Acute respiratory distress syndrome (ARDS); hypochlorous acid (HOCl); inflammatory response; oxidative stress biomarkers | ||||
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