Combined letrozole with clomiphene citrate versus letrozole only in induction of ovulation in polycystic ovary syndrome patients (A Randomized controlled trial)
Badr, F., El-Gazzar, A., Negm, A., Saad, A. (2022). Combined letrozole with clomiphene citrate versus letrozole only in induction of ovulation in polycystic ovary syndrome patients (A Randomized controlled trial). EKB Journal Management System, 26(3), 33-39. doi: 10.21608/egyfs.2022.260531
Faten Samir Ali Badr; Ali Mahmoud Kotb El-Gazzar; Aziza Ali Negm; Ahmed Samy Saad. "Combined letrozole with clomiphene citrate versus letrozole only in induction of ovulation in polycystic ovary syndrome patients (A Randomized controlled trial)". EKB Journal Management System, 26, 3, 2022, 33-39. doi: 10.21608/egyfs.2022.260531
Badr, F., El-Gazzar, A., Negm, A., Saad, A. (2022). 'Combined letrozole with clomiphene citrate versus letrozole only in induction of ovulation in polycystic ovary syndrome patients (A Randomized controlled trial)', EKB Journal Management System, 26(3), pp. 33-39. doi: 10.21608/egyfs.2022.260531
Badr, F., El-Gazzar, A., Negm, A., Saad, A. Combined letrozole with clomiphene citrate versus letrozole only in induction of ovulation in polycystic ovary syndrome patients (A Randomized controlled trial). EKB Journal Management System, 2022; 26(3): 33-39. doi: 10.21608/egyfs.2022.260531

Combined letrozole with clomiphene citrate versus letrozole only in induction of ovulation in polycystic ovary syndrome patients (A Randomized controlled trial)

The Egyptian Journal of Fertility of Sterility
Article 4, Volume 26, Issue 3, September 2022, Page 33-39  XML
Document Type: Original Article
DOI: 10.21608/egyfs.2022.260531
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Authors
Faten Samir Ali Badr1; Ali Mahmoud Kotb El-Gazzar2; Aziza Ali Negm3; Ahmed Samy Saad4
1M.B.B.Ch., Faculty of Medicine Cairo University (2012) (Resident of Obstetrics & Gynecology at Imbaba General Hospital) 358 Villa ,Elfardos in front of Dream Land
2Professor of Obstetrics and Gynecology - Faculty of Medicine - Benha University
3Lecturer of Obstetrics and Gynecology - Faculty of Medicine - Benha University.
4Assistant Professor of Obstetrics and Gynecology -Faculty of Medicine - Benha University.
Abstract
Objective: to compare adding clomiphene citrate to letrozole in comparison with letrozole only Patients and method : A total of 64 infertile woman with PCOS were assessed in this randomized controlled trial in Department of Obstetrics and Gynecology at Imbaba General hospital and Banha university hospital .
Results: The serum pregnancy test was positive in only (6,3%) group A who receive letrazole alone while shows (12.5%) in group B who took combined therapy with no significance in P value(0.39) so group B shows higher pregnancy rates, The six weeks pulsations shows higher percentages in group B (9.4%) in compare to Group A (3.1%) with P value of (0.3) , There is good significance in the number of follicles (with P value 0.006) with appearance of one follicle in group B was higher than group A (68.8% in group B versus 37.5% in group A) ,Also the appearance of 2 mature follicles happen only in group B (6.3%). the follicular size appeared significance with P value (<0.001) as group B ranges (20.21+_1.47) versus group A (17.17+-0.94 ), Endometrial thickness also show significance with P value (<0.001) with ranges (10.06+_1.6) in group B which has better ranges than group A (8.13+_1.79).
Conclusion: combined letrazole plus CC and letrazole alone seem to be two effective approaches, with letrazole plus CC showed better ovulation results and hence better pregnancy rate outcome.
Keywords
Keywords: PCOS; clomiphene citrate; letrozole; Insulin resistance
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