Evaluation of Certain Physiological Biomarkers in Iraqi Endometrial Carcinoma Patients | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 113, Volume 89, Issue 1, October 2022, Page 4854-4858 PDF (431.09 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2022.260752 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Hajer Sabah Hameed; Jabbar H. Yenzeel; Majeed A. Sabbah | ||||
| Biology/collage of sciences/ university of Baghdad/ Baghdad/ Iraq | ||||
| Abstract | ||||
| Background: Endometrial Cancer (EC) is the malignant tumor originating from endometrium cell (lining of the uterus). EC incidence and mortality have increased in recent years. Routinely used methods for EC diagnosis and treatment are histopathological tissue culture after surgery and postoperative radiotherapy, however there is still not enough efficient treatment for recurrence or progression of this disease. So, there is a critical need for further EC identification by new biological ways for the prognostic diagnosis of it. Objective: This study aimed to look for ways by which could help in diagnosis of EC before the hysterectomy. Materials and Methods: 55 patients with EC and 57 healthy women were involved in this study (up to 45 years) during their attendance at the Medicine City Hospital of Baghdad and Al-Yarmouk Hospital. The study was conducted from October 2020 to October 2021. Via vein puncture collection of blood samples from each women participated in this study for measurement of the levels of some proteins including Hepcidin hormone (hepc), Human epididymis protein-4 (HE-4), Transforming growth factor-beta (TGF-β) and CRP biomarker levels in serum of EC and healthy women by ELIZA method. Results: This study showed a highly significant (P≤0.01) increase in TGF- β and HE4 in EC patients compared with healthy control. Hepc and CRP also revealed a highly significant (P≤0.01) increase in EC patients’ women when compared to healthy control. Conclusion: It can be concluded that TGF- β and HE-4 proteins could be used in the early diagnosis for EC. Addition of hepcidin and CRP estimation to TGF- β and HE-4 proteins results in accurate prognostic diagnosis. | ||||
| Keywords | ||||
| Endometrial cancer; Hepcidin; Transforming growth factor-β; Human epididymis protein- 4; C-reactive protein | ||||
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