Neutral Protamine Hagedorn versus Glargine 100 International Units among Elderly Patients with Type 2 Diabetes Fasting Ramadan | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 115, Volume 89, Issue 1, October 2022, Page 4865-4869 PDF (432.45 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2022.260756 | ||||
 View on SCiNiTO | ||||
| Author | ||||
Hossam Arafa Ghazi  
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| Lecturer of Internal medicine Faculty of medicine Mansoura University | ||||
| Abstract | ||||
| Background: One of the main five pillars of Islam is Ramadan fasting. In Egypt, Muslims usually fast from 12 to 16 hours. Neutral Protamine Hagedorn (NPH) is cheaper basal insulin in comparison to Glargine U100, and has shorter duration of action. Main fear from insulin usage in elderly with type 2 diabetes mellitus (T2DM) in Ramadan is hypoglycaemia. Objective: The aim of the present study was to compare the safety and efficacy NPH versus Glargine U100 among elderly patients fasting Ramadan. Patients and methods: The study was conducted on 100 patients of both genders with T2DM aged 60 years and more. Comprehensive geriatric assessment was done. Weight, glycated haemoglobin (HbA1c) and creatinine (1 month before Ramadan and 2 months after Ramadan) were estimated. Moreover, numbers of documented hypoglycaemia and days of breaking fast were compared. Results: The mean age of the patients was 65.9 (SD 3.6) years among glargine group, and 66.2 (SD 3.7) years among NPH group, and 58 of the participants were females. There was significant difference in days to break fasting from hypoglycemia [3 days in NPH group versus 10 days in glargine group (P-value 0.03)]. No statistical difference regarding weight and creatinine before and after Ramadan among both groups. Conclusion: NPH could be a better option than Glargine U100 for elderly patients with T2DM willing to fast Ramadan, with less reported attacks of hypoglycaemia and lower cost. | ||||
| Keywords | ||||
| Elderly; Type 2 Diabetes Mellitus; Ramadan Fasting; NPH; Glargine U100 | ||||
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