Effect of Pentoxifylline on Late-onset Sepsis and Protein C Level in Preterm Neonates: a Double-blinded Randomized Controlled Trial
El Sebaie, D., Mansi, Y., Nasr, A., Khairy, S., Tosson, A. (2022). Effect of Pentoxifylline on Late-onset Sepsis and Protein C Level in Preterm Neonates: a Double-blinded Randomized Controlled Trial. EKB Journal Management System, 89(1), 4930-4937. doi: 10.21608/ejhm.2022.260862
Dahlia El Sebaie; Yasmeen Mansi; Aml S. Nasr; Shahenda Abdelaziz Khairy; Angie M.S. Tosson. "Effect of Pentoxifylline on Late-onset Sepsis and Protein C Level in Preterm Neonates: a Double-blinded Randomized Controlled Trial". EKB Journal Management System, 89, 1, 2022, 4930-4937. doi: 10.21608/ejhm.2022.260862
El Sebaie, D., Mansi, Y., Nasr, A., Khairy, S., Tosson, A. (2022). 'Effect of Pentoxifylline on Late-onset Sepsis and Protein C Level in Preterm Neonates: a Double-blinded Randomized Controlled Trial', EKB Journal Management System, 89(1), pp. 4930-4937. doi: 10.21608/ejhm.2022.260862
El Sebaie, D., Mansi, Y., Nasr, A., Khairy, S., Tosson, A. Effect of Pentoxifylline on Late-onset Sepsis and Protein C Level in Preterm Neonates: a Double-blinded Randomized Controlled Trial. EKB Journal Management System, 2022; 89(1): 4930-4937. doi: 10.21608/ejhm.2022.260862

Effect of Pentoxifylline on Late-onset Sepsis and Protein C Level in Preterm Neonates: a Double-blinded Randomized Controlled Trial

The Egyptian Journal of Hospital Medicine
Article 126, Volume 89, Issue 1, October 2022, Page 4930-4937  XML PDF (603.54 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2022.260862
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Authors
Dahlia El Sebaie email orcid ; Yasmeen Mansi; Aml S. Nasr; Shahenda Abdelaziz Khairy email ; Angie M.S. Tosson
The neonatal intensive care unit ,Maternity hospital ,Ain Shams University hospital.
Abstract
Background: Pathological coagulation system activation is linked to neonatal sepsis, which leads to disseminated intravascular coagulation. Late-onset sepsis (LOS) in preterm neonates leads to serious morbidities and increased mortality. Aim and objectives: The purpose of this research was to assess how pentoxifylline affectes protein C in septic preterm infants as well as their clinical development and outcomes.
Patients and methods: Eighty preterm newborns who were hospitalized in Kasr Alaini, Cairo University Hospital's neonatal critical care units and with clinical or blood culture-proven LOS participated in this double-blinded, randomized controlled experiment. The pentoxifylline group got pentoxifylline (5 mg/kg/hour for six hours), whereas the control group received normal saline as a placebo. Both infusions were administrated for six successive days. Protein C levels were measured before and after the intervention.
Result: Gram-negative sepsis was predominant with Klebsiella pneumonia being the most common isolated organism. After the intervention, there was a significant increase in protein C levels in the pentoxifylline group (P value = 0.020). Significant reductions in the duration of antimicrobial therapy,duration of hospital stay in survivors and continuous positive airway pressure therapy, (P values =0.001, 0.012 and 0.03 respectively) were documented, as well as the decreased requirement for plasma transfusions (P value = 0.03).
Conclusion: In preterm newborns with LOS, pentoxifylline has a good impact on the protein C system and lengths of antibiotic treatment, hospital stay and continuous positive airway pressure therapy.
 
 
Keywords
Coagulation; Neonate; Pentoxifylline; Protein C; Sepsis
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