The potential protective role of flaxseed extract on ventral prostate in a rat model of streptozotocin-induced diabetes: A histological and immunohistochemical study | ||||
| Egyptian Journal of Histology | ||||
| Article 15, Volume 42, Issue 2, June 2019, Page 425-436 PDF (4.73 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejh.2019.6454.1047 | ||||
 View on SCiNiTO | ||||
| Author | ||||
Amira Adly Kassab  
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| Histology and Cell Biology Department, Faculty of Medicine,Tanta University, Egypt | ||||
| Abstract | ||||
| Background: Diabetes mellitus is a chronic disorder that can affect the reproductive system leading to fertility dysfunction. The prostate plays an important role in the reproduction and it is a frequent target for diabetic complications. Flaxseed is a promising alternative in many chronic diseases due to its health benefits. It has a proposed role in controlling diabetes due to its wide pharmacological activities. im: Evaluation of the possible protective role of flaxseed extract on the ventral prostate gland of diabetic rats. Materials & Methods: Fifty adult male albino rats were used as a control group and experimental group that received a single intra-peritoneal injection of streptozotocin (60 mg/kg). The experimental rats with confirmed diabetes mellitus were subdivided into: diabetic group that kept without treatment and diabetic–flaxseed group (400 mg/kg/day orally). After four weeks, specimens of the ventral prostate lobes were processed for histological and immunohistochemical study using antibodies against Bcl-2, α-smooth muscle actin and androgen receptor. Results: In comparison with the control, specimens of the diabetic group showed glandular epithelial atrophy with thickening of the fibromuscular stroma. Reduced epithelial height and a statistically significant decrease in Bcl2 immunoexpression were observed in the epithelial cells. A statistically significant increase in the collagen fibers and α-SMA immunoexpression was seen in the stroma. Androgen receptor immunoreactivity was significantly decreased in both epithelial and stromal cells. In contrast, minimal changes appeared in diabetic-flaxseed group that received flaxseed extract. Conclusion: Diabetes induced structural alterations in the ventral prostate gland of rats. Administration of flaxseed extract attenuated these effects and partially preserved the glandular structure. | ||||
| Keywords | ||||
| Diabetes mellitus; Flaxseed; prostate gland | ||||
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