Evolving phenotype of systemic lupus erythematosus patients and correlation with antibody against c1q: A review article | ||||
| SVU-International Journal of Medical Sciences | ||||
| Article 31, Volume 6, Issue 1, January 2023, Page 291-301 PDF (196.63 K) | ||||
| Document Type: Reviews Articles. | ||||
| DOI: 10.21608/svuijm.2022.158094.1392 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Khalid Abd El Monem Zaki1; Mohamed Ismail Abdelkareem2; Wael Abd El Mohsen Abady3; Asmaa Nafady4; Zeinab Abd El Razek El Tieb  3
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| 1Physical Medicine, Rheumatology and Rehabilitation Department, Faculty of Medicine, Al-Azhar University (Cairo Branch), Cairo, Egypt. | ||||
| 2Physical Medicine, Rheumatology and Rehabilitation Department, Faculty of Medicine, Al-Azhar University (Assiut Branch), Assiut, Egypt. | ||||
| 3Physical Medicine, Rheumatology and Rehabilitation Department, Faculty of Medicine, South Valley University, Qena, Egypt. | ||||
| 4Clinical Pathology Department, Faculty of Medicine, South Valley University, Qena, Egypt. | ||||
| Abstract | ||||
| Background: Systemic lupus erythematosus (SLE) is a persistent illness that results in inflammation of connective tissues, including cartilage and the lining of blood vessels, which give structures throughout the body their flexibility and strength. A multi-system autoimmune illness, SLE affects several organ systems. There are several phenotypes of the illness, and clinical symptoms in individuals may range from modest mucocutaneous signs to severe central nervous system involvement affecting multiple organs. SLE is an illness that develops along many immune-pathogenic pathways. Aim: To explore various phenotypes of SLE and possible role of anti-C1q antibodies in SLE Conclusion: Anti-C1q antibodies were strongly associated with lupus disease activity in SLE patients, suggesting that it may be a reliable, sensitive, and non-invasive serological marker for SLE patients with active SLE disease. | ||||
| Keywords | ||||
| Anti-C1q; Systemic lupus erythematosus; Lupus nephritis; Complement; Proteinuria | ||||
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