Anatomical and histological study on thymus development in the embryo and adult mice

Zaghloul, Dorreia AbdAllah M.; AbdErahim, Eman Ahmad; Abd El_Raheem, Basma Ashraf Yousef; Mohamed, Mohamed Hashem

doi:10.21608/svuijm.2022.163413.1409

	Anatomical and histological study on thymus development in the embryo and adult mice
SVU-International Journal of Medical Sciences
Article 50, Volume 5, Issue 2, July 2022, Page 533-546 PDF (3.49 MB)
Document Type: Original research articles
DOI: 10.21608/svuijm.2022.163413.1409
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Authors
Dorreia AbdAllah M. Zaghloul¹; Eman Ahmad AbdErahim²; Basma Ashraf Yousef Abd El_Raheem³; Mohamed Hashem Mohamed ¹
¹Department of Human Anatomy and Embryology, Faculty of Medicine, Assuit University, Assiut, Egypt.
²Histology Department, Faculty of Medicine, South Valley University, Qena, Egypt.
³Human Anatomy Department, Faculty of Medicine, South Valley University, Qena, Egypt.
Abstract
Background: The thymus is the location of T cell development, where lymphoid precursors mature and are exported to the periphery through a sequence of interactions with the thymic epithelium. Objectives: To assess the anatomical and histological study on the development of the thymus in the embryo and adult mice. Materials and methods: This study was developmental; fifty mice were divided randomly into 5 groups; group A: Pregnant female mice were dissected at the end of the 1^st week of gestation to get their embryos. Group B: Pregnant female mice were dissected at the end of the 2^nd week of gestation to get their embryos. Group C: Pregnant female mice were left to deliver their fetuses. Group D: Fetuses was left to complete their 1^st week. Group E was designed as the control group in which the adult male and female mice were dissected and prepared for histological examination to compare their thymus with the embryonic and fetal thymus. Results: All animals of the group A had no thymus gland while all the other mice had thymus gland. Thymus appeared lobulated with no differentiation between the cortex and the medulla in the newborn age. Hassle's corpuscles could be detected at the 6^th postnatal age. Conclusion: Age-related differences in the morphology and histology of TH reflects the development of T cell and immunity and its crucial role in immune disorders. Mice TH gain full maturity by the end of 1^st postnatal week and involution appears in the 6^th postnatal week of age. The distinction between the medulla and cortex gradually disappears as people age.
Keywords
Anatomical; Histological; Thymus; Embryo; Adult mice


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