HLA DRB1 Alleles in Association with Chronic Hepatitis C Virus Infection and Autoimmune Hepatitis
Shalaa, A., Morsi, M., Ahmed, M., Al Zaafarany, K., Arafa, S. (2022). HLA DRB1 Alleles in Association with Chronic Hepatitis C Virus Infection and Autoimmune Hepatitis. EKB Journal Management System, 31(4), 93-101. doi: 10.21608/ejmm.2022.262693
Amira Shalaa; Mona Morsi; Mohamed Abd elrahman Ahmed; Khalid Al Zaafarany; Shams Abd elfattah Arafa. "HLA DRB1 Alleles in Association with Chronic Hepatitis C Virus Infection and Autoimmune Hepatitis". EKB Journal Management System, 31, 4, 2022, 93-101. doi: 10.21608/ejmm.2022.262693
Shalaa, A., Morsi, M., Ahmed, M., Al Zaafarany, K., Arafa, S. (2022). 'HLA DRB1 Alleles in Association with Chronic Hepatitis C Virus Infection and Autoimmune Hepatitis', EKB Journal Management System, 31(4), pp. 93-101. doi: 10.21608/ejmm.2022.262693
Shalaa, A., Morsi, M., Ahmed, M., Al Zaafarany, K., Arafa, S. HLA DRB1 Alleles in Association with Chronic Hepatitis C Virus Infection and Autoimmune Hepatitis. EKB Journal Management System, 2022; 31(4): 93-101. doi: 10.21608/ejmm.2022.262693

HLA DRB1 Alleles in Association with Chronic Hepatitis C Virus Infection and Autoimmune Hepatitis

Egyptian Journal of Medical Microbiology
Volume 31, Issue 4, October 2022, Page 93-101  XML PDF (357.46 K)
Document Type: New and original researches in the field of Microbiology.
DOI: 10.21608/ejmm.2022.262693
View on SCiNiTO View on SCiNiTO
Authors
Amira Shalaa1; Mona Morsi2; Mohamed Abd elrahman Ahmed3; Khalid Al Zaafarany4; Shams Abd elfattah Arafa email orcid 5
1Medical Microbiology and Immunology Faculty of Medicine Alexandria University
2Medical Microbiology and Immunology Department, Faculty of Medicine, University of Alexandria, Egypt
3Clinical Pathology, Armed Forces Medical Academy, Alexandria, Egypt
4Faculty of Medicine Alexandria University
5Medical microbiology and immunology, faculty of medicine, Alexandria university
Abstract
Background: Hepatitis C virus is a hepatotropic and lymphotropic virus that has been associated with various diseases and syndromes. Autoimmune hepatitis is a chronic disease of unknown etiology, marked by the continuous inflammation of hepatocytes and necrosis and has a tendency to advance to cirrhosis. Objective: A comparative study between cases of chronic HCV infection and AIH cases regarding different parameters including their genetic association with HLA class II alleles: DRB1*01* - DRB115. Methodology: The study included Eighty subjects, Group I: 30 chronic HCV, Group II: 30 AIH, Group III: 20 healthy controls. HLA Typing was performed using a line probe assay. Results: HLA DRB1∗07, DRB1∗11 were highly associated with HCV clinical cases. DRB1*3 and DRB1*5 were the predominant alleles in AIH (representing 66.7% and 53.3% respectively). Conclusion: Certain HLA alleles of class II could be linked to hepatitis cases (either caused by HCV or autoimmune) and can predict clinical course and outcome of the disease.
Keywords
HCV; Autoimmune hepatitis; HLA typing; HLA DRB; autoantibodies
Statistics
Article View: 160
PDF Download: 113