Protective effect of curcumin against acetamiprid- induced neurotoxicity in male albino rats
Abd El-Kader, A., Awadalla, E., salah Eldin, A., Mohamed, Z., Mohamed, O. (2022). Protective effect of curcumin against acetamiprid- induced neurotoxicity in male albino rats. EKB Journal Management System, 3(3), 303-312. doi: 10.21608/aujes.2022.150987.1084
Abd El-Kader M Abd El-Kader; Eatemad Ahmed Awadalla; Alaa Eldin salah Eldin; Zainab A. Mohamed; Ola Mohamed. "Protective effect of curcumin against acetamiprid- induced neurotoxicity in male albino rats". EKB Journal Management System, 3, 3, 2022, 303-312. doi: 10.21608/aujes.2022.150987.1084
Abd El-Kader, A., Awadalla, E., salah Eldin, A., Mohamed, Z., Mohamed, O. (2022). 'Protective effect of curcumin against acetamiprid- induced neurotoxicity in male albino rats', EKB Journal Management System, 3(3), pp. 303-312. doi: 10.21608/aujes.2022.150987.1084
Abd El-Kader, A., Awadalla, E., salah Eldin, A., Mohamed, Z., Mohamed, O. Protective effect of curcumin against acetamiprid- induced neurotoxicity in male albino rats. EKB Journal Management System, 2022; 3(3): 303-312. doi: 10.21608/aujes.2022.150987.1084

Protective effect of curcumin against acetamiprid- induced neurotoxicity in male albino rats

Aswan University Journal of Environmental Studies
Article 4, Volume 3, Issue 3, October 2022, Page 303-312  XML PDF (483.5 K)
Document Type: Original Research
DOI: 10.21608/aujes.2022.150987.1084
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Authors
Abd El-Kader M Abd El-Kader1; Eatemad Ahmed Awadalla email orcid 2; Alaa Eldin salah Eldin3; Zainab A. Mohamed4; Ola Mohamed5
1Zoology department, Faculty of Science, Aswan University, Aswan, Egypt
2Zoology Dep. , Faculty of Science, Aswan University, Aswan, Egypt
3Professor of molecular biology, zoology department, faculty of science, Aswan university.
4Zoology department, Faculty of Science, Aswan University, 81582 Aswan, Egypt
5Zoology department, Faculty of Science, Aswan University, Aswan, Egypt.
Abstract
Acetamiprid (ACMP) is a widely used neonicotinoid that is frequently favored in pest control. After imidacloprid, it is the most commonly manufactured neonicotinoid. It was established that ACMP exhibits brain toxic impact at sub-lethal doses. Curcumin (Cur) a natural polyphenol has been conveyed to possess neuroprotective activity by reducing oxidative stress. The purpose of this study was to look into the neuroprotective role of curcumin against acetamiprid induced neuro-toxicity. In the current study, seventy adult male albino rats were divided into two main groups 20 days and 40 days each of them subdivided into 5 groups consist of: control, vehicle (DMSO), Cur, ACMP and ACMP +Cur group. The current study found that acetamiprid administration resulted in a significant increase in nitric oxide levels (NO) with histopathological changes in brain hippocampus tissue. Curcumin co-administration with acetamiprid significantly reduced nitric oxide levels and protected against acetamiprid-mediated structural changes in the hippocampal tissue.
Keywords
Curcumin; Acetamiprid; brain; Nitric oxide
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