Aspartic Acid Ameliorates Cholestasis in Bile Duct-Ligated Rats | ||||
| Egyptian Journal of Histology | ||||
| Article 26, Volume 46, Issue 4, December 2023, Page 1900-1910 PDF (1.01 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejh.2022.158308.1761 | ||||
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| Authors | ||||
Mahmoud Fawzy Elnagar  1; Yomna Ibrahim Mahmoud2; Mohamed Abdelmordy Mohamed2
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| 1Zoology Department, Faculty of Science, Ain Shams University. | ||||
| 2Zoology Department, Faculty of Science, Ain Shams University | ||||
| Abstract | ||||
| Background: Amino acids are promising agents in a variety of therapeutic fields including proliferation management. D-aspartic acid (DAA) is a non-essential amino acid, which occurs in many marine and terrestrial animals and has alleviative effects against many liver diseases such as hepatic steatosis, liver fibrosis and lipopolysaccharide-induced liver injury, but its effect has never been tested against cholestasis. Aim of the Work: Thus, this study tests the effect of D-aspartic acid compared to that of the therapeutic drug for treating cholestatic liver diseases “ursodeoxycholic acid, UDCA”. Patients and Methods: Cholestasis was induced by bile duct ligation (BDL) in adult male albino rats. Three weeks post operation, the animals were allotted into 5 groups: Sham group, bile duct-ligated group, bile duct-ligated rats treated with D-aspartic acid group, bile duct-ligated rats treated with ursodeoxycholic acid group and bile duct-ligated rats treated with D-aspartic acid and ursodeoxycholic acid group, where treatments were orally administered during the fourth week. Results: Bile duct-ligated rats suffered from lower body weight and higher liver relative weight, in addition to significant increase in the liver biomarkers alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, direct bilirubin, and total bilirubin in comparison with those of sham-operated rats. Histologically, these animals suffered from liver fibrosis, disorganized hepatic lobules, necrosis, and bile duct hyperplasia. After the administration of D-aspartic acid or/ and ursodeoxycholic acid, cholestasis-associated changes were significantly alleviated, especially in the group treated with D-aspartic acid and ursodeoxycholic acid together. Conclusion: D-aspartic acid has a therapeutic effect in cholestasis of liver in bile duct-ligated rats, especially when used in combination with ursodeoxycholic acid. | ||||
| Keywords | ||||
| Bile duct ligation; cholestasis; d-aspartic acid; rats; ursodeoxycholic acid | ||||
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