Design, Synthesis, and Biological Evaluation of N-Phenylpyrazole Derivatives Featuring Nitrogen-Containing Side Chains as Potent Antitumor Agents
Hafez, H., El-Gazzar, A., Ali, A., Alakhras, A. (2019). Design, Synthesis, and Biological Evaluation of N-Phenylpyrazole Derivatives Featuring Nitrogen-Containing Side Chains as Potent Antitumor Agents. EKB Journal Management System, 62(6), 1093-1104. doi: 10.21608/ejchem.2019.6773.1565
Hend Nagah Hafez; Abdel-Rhman Barakat El-Gazzar; Ahmed Salah Ali; Abbas Alakhras Ishak Alakhras. "Design, Synthesis, and Biological Evaluation of N-Phenylpyrazole Derivatives Featuring Nitrogen-Containing Side Chains as Potent Antitumor Agents". EKB Journal Management System, 62, 6, 2019, 1093-1104. doi: 10.21608/ejchem.2019.6773.1565
Hafez, H., El-Gazzar, A., Ali, A., Alakhras, A. (2019). 'Design, Synthesis, and Biological Evaluation of N-Phenylpyrazole Derivatives Featuring Nitrogen-Containing Side Chains as Potent Antitumor Agents', EKB Journal Management System, 62(6), pp. 1093-1104. doi: 10.21608/ejchem.2019.6773.1565
Hafez, H., El-Gazzar, A., Ali, A., Alakhras, A. Design, Synthesis, and Biological Evaluation of N-Phenylpyrazole Derivatives Featuring Nitrogen-Containing Side Chains as Potent Antitumor Agents. EKB Journal Management System, 2019; 62(6): 1093-1104. doi: 10.21608/ejchem.2019.6773.1565

Design, Synthesis, and Biological Evaluation of N-Phenylpyrazole Derivatives Featuring Nitrogen-Containing Side Chains as Potent Antitumor Agents

Egyptian Journal of Chemistry
Article 10, Volume 62, Issue 6, June 2019, Page 1093-1104  XML PDF (1.18 MB)
Document Type: Original Article
DOI: 10.21608/ejchem.2019.6773.1565
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Authors
Hend Nagah Hafez email orcid 1; Abdel-Rhman Barakat El-Gazzar2; Ahmed Salah Ali3; Abbas Alakhras Ishak Alakhras4
1Photochemistry department, National Research center, Chemical Industrial Section, DokKi, Gizza
2Al-Imam Mohammad Ibn Saud Islamic University (IMSIU), Faculty of Science, Department of Chemistry
3Photochemistry Department, National Research Centre, Cairo, Egypt
4Al-Imam Mohammad Ibn Saud Islamic University (IMSIU), Faculty of Science, Department of Chemistry, Riyadh
Abstract
A series of novel N-phenylpyrazole containing acyl derivatives 3a, b, N-methylimidiazole 4, thiazole derivatives 6a-d, benzimidiazole derivatives 7a-c pyrane and pyridine 8, 9a, b, tetrazole 10, pyridodipyrimidine 11, and dihydronaphthaline derivatives 15 have been synthesized. The structure of the newly synthesized compounds was elucidated by IR, 1H NMR, 13C NMR, Mass spectra and Elemental analysis. The newly synthesized compounds were evaluated for their antitumor activity against three tumor cell lines, liver cancer (HepG2), human colonic carcinoma cell line (HCT-116), and human breast adenocarcinoma (MCF-7). Compounds 6d, 7b, c, 9b and 11 exhibited higher antitumor activity compared with the reference drug Doxorubicin.
Keywords
N-pyrazolyl derivatives; hexahydropyridodipyrimidine-4; 6-dione; antitumor activity
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