Regioselective synthesis of N-alkylated 4,6-diaryl-2-oxonicotinonitrile | ||||
Bulletin of Faculty of Science, Zagazig University | ||||
Article 6, Volume 2022, Issue 3, October 2022, Page 59-68 | ||||
Document Type: Original Article | ||||
DOI: 10.21608/bfszu.2022.139178.1140 | ||||
View on SCiNiTO | ||||
Authors | ||||
Hassan A El-Sayed 1; Sammar ع Mohamed 2; Ahmed H. Moustafa3; Aya A Aymn1 | ||||
1Department of Chemistry, Faculty of Science, Zagazig University, | ||||
2الزقازيق | ||||
3Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt. | ||||
Abstract | ||||
In the present work 4,6-diaryl-2-oxonicotinonitrile 1 reacts with serious of alkylating agents (ethyl bromoacetate, allyl bromide, propargyl bromide, chloroacetonitrile, chloroacetone, chloroacetic acid, epichlorohydrine, benzyl chloride, 1,3-dichloro isopropanol, 1,2-dichloroethane and 1,3-dibromopropane) by using K2CO3- NPs to form N-alkylated nicotinonitrile derivatives 2a-k. Also, the compounds 2j and 2k were reacted with another molecule of 2-oxonicotinonitrile 1 in the presence of K2CO3-NPs to afford the desired bis-pyridine ethane 4 and bi-pyridine propane 5, respectivelyIn the present work 4,6-diaryl-2-oxonicotinonitrile 1 reacts with serious of alkylating agents (ethyl bromoacetate, allyl bromide, propargyl bromide, chloroacetonitrile, chloroacetone, chloroacetic acid, epichlorohydrine, benzyl chloride, 1,3-dichloro isopropanol, 1,2-dichloroethane and 1,3-dibromopropane) by using K2CO3- NPs to form N-alkylated nicotinonitrile derivatives 2a-k. Also, the compounds 2j and 2k were reacted with another molecule of 2-oxonicotinonitrile 1 in the presence of K2CO3-NPs to afford the desired bis-pyridine ethane 4 and bi-pyridine propane 5, respectively.In the present work 4,6-diaryl-2-oxonicotinonitrile 1 reacts with serious of alkylating agents (ethyl bromoacetate, allyl bromide, propargyl bromide, chloroacetonitrile, chloroacetone, chloroacetic acid, epichlorohydrine, benzyl chloride, 1,3-dichloro isopropanol, 1,2-dichloroethane and 1,3-dibromopropane) by using K2CO3- NPs to form N-alkylated nicotinonitrile derivatives 2a-k. Also, the compounds 2j and 2k were reacted with another molecule of 2-oxonicotinonitrile 1 in the presence of K2CO3-NPs to afford the desired bis-pyridine ethane 4 and bi-pyridine propane 5, respectively. | ||||
Keywords | ||||
K2CO3 Nano-catalyst; N-alkylation; 2-oxonicotinonitrile; bis compounds | ||||
Statistics Article View: 118 PDF Download: 12 |
||||