Circulating and Mucosal Associated Type 2 Innate Lymphoid Cells in Asthma
Alqurashi, L., mohamed, H., El-Gebaly, A., El-Akabawy, N., Samra, S., Zake, L. (2022). Circulating and Mucosal Associated Type 2 Innate Lymphoid Cells in Asthma. EKB Journal Management System, 28(6.1), 265-275. doi: 10.21608/zumj.2022.159017.2631
Lobna A. Alqurashi; hoda fathi mohamed; Ahmed M. El-Gebaly; Nadia M. El-Akabawy; Saad R. Samra; Lamiaa Gaber Zake. "Circulating and Mucosal Associated Type 2 Innate Lymphoid Cells in Asthma". EKB Journal Management System, 28, 6.1, 2022, 265-275. doi: 10.21608/zumj.2022.159017.2631
Alqurashi, L., mohamed, H., El-Gebaly, A., El-Akabawy, N., Samra, S., Zake, L. (2022). 'Circulating and Mucosal Associated Type 2 Innate Lymphoid Cells in Asthma', EKB Journal Management System, 28(6.1), pp. 265-275. doi: 10.21608/zumj.2022.159017.2631
Alqurashi, L., mohamed, H., El-Gebaly, A., El-Akabawy, N., Samra, S., Zake, L. Circulating and Mucosal Associated Type 2 Innate Lymphoid Cells in Asthma. EKB Journal Management System, 2022; 28(6.1): 265-275. doi: 10.21608/zumj.2022.159017.2631

Circulating and Mucosal Associated Type 2 Innate Lymphoid Cells in Asthma

Zagazig University Medical Journal
Article 1047, Volume 28, Issue 6.1, November 2022, Page 265-275  XML PDF (360.49 K)
Document Type: Original Article
DOI: 10.21608/zumj.2022.159017.2631
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Authors
Lobna A. Alqurashi1; hoda fathi mohamed2; Ahmed M. El-Gebalyorcid 3; Nadia M. El-Akabawy4; Saad R. Samra5; Lamiaa Gaber Zake email orcid 6
1Medical micro biology and immunology Department, Faculty of medicine, Zagazig University, Zagazig, Egypt
2faculty of medicine zagazig university clinical pathology department
3Tropical Medicine, Faculty of Medicine, Zagazig University, Zagazig, Sharkia, Egypt
4Department of Medical Histology and Cell Biology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
5Chest department, Faculty of medicine, Zagazig University, Zagazig, Egypt
6Department of Chest diseases, Faculty of Medicine, Zagazig University, Egypt
Abstract
Abstract
Background: Type 2 innate lymphoid cells (ILC2s) are introduced as a key player in type 2 inflammation. Objectives: To assess the correlation between ILC2s in peripheral blood, sputum, and colonic biopsies among patients with asthma, and to assess the relation between ILC2s frequency and severity of asthma. Methods: ILC2s numbers were assessed in peripheral blood, and sputum among 29 patients with asthma (asthma group) and 29 healthy controls (control group). Colonic biopsies were obtained from twelve mild to moderate asthma patients and nine healthy controls. ILC2s were determined by multicolor flow cytometer in all specimens. Results: ILC2s numbers in peripheral blood were higher among the asthma group compared to the control group (P
Keywords
Keywords: Innate lymphoid cells; asthma; peripheral blood; colon; sputum
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