Hands-on Synthetic Approaches and Biological Activities of Anthranilic Acid Derivatives: A mini-review

Nasr, Tamer Mohamed; Aboshanab, Ahmed Mordy; Abouzid, Khaled Abouzid Mohamed; Zaghary, Wafaa Abdou

doi:10.21608/ejchem.2022.148409.6426

	Hands-on Synthetic Approaches and Biological Activities of Anthranilic Acid Derivatives: A mini-review
Egyptian Journal of Chemistry
Volume 66, Issue 7, July 2023, Page 329-343 PDF (316.38 K)
Document Type: Review Articles
DOI: 10.21608/ejchem.2022.148409.6426
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Authors
Tamer Mohamed Nasr¹; Ahmed Mordy Aboshanab ²; Khaled Abouzid Mohamed Abouzid ³; Wafaa Abdou Zaghary⁴
¹Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Helwan University, Helwan, Cairo, Egypt. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, MTI University, Cairo, Egypt.
²Pharmaceutical Chemistry department, Faculty of Pharmacy, Helwan University, Cairo, Egypt
³Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ain Shams University, Abbassia, Cairo , Egypt Department of Organic and Medicinal Chemistry, Faculty of Pharmacy, University of Sadat City, Sadat City , Egypt
⁴Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Helwan University, Helwan, Cairo, Egypt.
Abstract
Anthranilic acid scaffold is a pivotal class of amino organic acids used for the construction of many organic candidates exhibiting a wide range of industrial, pharmaceutical, and biological activities. In addition, anthranilic acid derivatives are considered a cheap and efficient stating precursor for the production and synthesis of various marketed available drugs like furosemide (diuretic), tranilast (antiallergic), betrixaban (anticoagulant) and analgesic & anti-inflammatory fenamates. Furthermore, numerous anthranilic acid analogs with potential anticancer, antimicrobial, insecticidal, antiviral, anti-inflammatory activities and other biological activities have been disclosed over the last thirty years. The current review represents a brief and simple summary of different synthetic methodologies and techniques applied for the construction and synthesis of different anthranilic acid analogs and derivatives along with a concise discussion of the potential therapeutic activity of these synthesized derivatives.
Keywords
Ullmann-Goldberg; ultrasonic irradiation; microwave irradiation; anticancer; Human aldo-keto reductase; HCV-NS5B; nuclear farnesoid x receptor


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