Correlation between Glycated Hemoglobin, Extra-cranial Carotid Artery Disease and Peripheral Arterial Disease in Type 2 Diabetic Patients with Coronary Artery Disease | ||||
| International Journal of Medical Arts | ||||
| Article 3, Volume 4, Issue 9, September 2022, Page 2633-2640 PDF (879.56 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ijma.2022.159085.1502 | ||||
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| Authors | ||||
Mohammed Nabil Darwish  1; Ahmed Mohammed Fahmy2; Mohammed Abomandour Mousa2; Ahmed Farouk Abdelrazek3
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| 1Department of Cardiology, National Institute of Diabetes & Endocrinology, Ministry of Health, Cairo, Egypt | ||||
| 2Department of Cardiology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt | ||||
| 3Department of Radio-diagnosis, National Institute of Diabetes & Endocrinology, Ministry of Health, Cairo, Egypt | ||||
| Abstract | ||||
| Background: Diabetes mellitus [DM] is the well-known endocrine problem where the body either doesn't deliver sufficient insulin or has a resistance to the circulating insulin. Atherosclerotic cardiovascular disease stays the chief reason of death and disability among diabetic patients, particularly in type II DM patients. Aim of the work: To correlate between glycated Hemoglobin [HBA1C], carotid, peripheral and coronary artery disease in type II DM patients. Patients and methods: This is an observational study of 122 type II DM patients who were admitted to National Institute of Diabetes and Endocrinology. A full history, a full clinical examination, 12 lead-ECG, Echocardiography, Carotid duplex, Ankle-brachial index [ABI] measurement, HbA1C and Invasive non emergent coronary angiography were done. Results: Carotid intima-media thickness [IMT] in patients with HbA1C >7% was significantly higher than those with HbA1C<7, HbA1C had a significant positive correlation with carotid IMT, ABI was significantly lower in patients with HbA1C>7% compared to those with HbA1C<7%, Number of diseased coronary vessels was significantly higher in patients with higher HbA1C >7% compared to those with HbA1C>7%, ABI had a significant negative correlation with number of diseased coronary vessels and IMT had a significant positive correlation with number of diseased coronary vessels in patients with higher HbA1C >7% with no significant correlation in those with HbA1C<7%. Conclusion: Our results showed a significant correlation between HbA1C and Carotid atherosclerosis, Peripheral artery disease [PAD] and Coronary Artery disease [CAD] severity based on number of diseased coronary vessels in uncontrolled T2DM patients. | ||||
| Keywords | ||||
| Glycated Hemoglobin; Carotid Artery; Carotid intima-media thickness; Ankle-brachial index; Diabetes Mellitus | ||||
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