Potential Protective Effects of Lemon Verbena (Aloysia Citriodora) Leaves Against Gastric Ulcer in Rats: Biological, Biochemical and Technological Studies | ||||
| مجلة بحوث التربية النوعية | ||||
| Article 3, Volume 2022, Issue 69, July 2022, Page 25-44 PDF (434.97 K) | ||||
| Document Type: مقالات علمیة محکمة | ||||
| DOI: 10.21608/mbse.2022.143713.1201 | ||||
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| Authors | ||||
basma elkhateeb1; Mohamed Elkabary   2
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| 1کلية الاقتصاد المنزلي - جامعة المنوفية | ||||
| 2کليه الاقتصاد المنزلي - جامعة المنوفية | ||||
| Abstract | ||||
| Lemon verbena (Aloysia citriodora) is a herbal that contains an excessive amount of phenols such as flavonoids that have been shown to help control digestive disorders. Therefore, this study aimed to evaluate the gastroprotective effects of Lemon verbena against gastric ulcers in rats induced by ethanol. Thirty male Albino rats were randomly divided into five groups (6/each). Rats were injected with ethanol to induce gastric ulcers. The antiulcer activities of lemon verbena leaves ethanol extract (LVEE) were estimated at different dose levels (50 and 100mg/kg body weight) and compared with Omeprazole (OMZ) used as a standard drug at dose (40mg/kg body weight). To estimate the potential mechanisms of action, data of the present study examined the levels of oxidative stress parameters. Gastric volume, pH, and other gastric lesion measurements as well as histological examination of gastric ulcers were performed. Rats treated with only ethanol (positive group) exhibited significant increases (P≤0.05) in their ulcer score, ulcer index (UI) and decreases antioxidant enzymes. Moreover, the levels Malondialdehyde (MDA) markedly increased in the positive group compared with the normal group. The pretreatment of rats with LVEE at different dose levels not only improved gastric lesions measurements and the activities of antioxidants but also remarkably decreased the MDA levels in gastric tissue. These findings suggest that LVEE potentially exerts its gastroprotective effects by stimulating antioxidant enzymes. Finally, lemon verbena leaves powder has been used in bread flour with the goal of producing a fortified bread that can be recommended for stomach ulcer patients. | ||||
| Keywords | ||||
| Peptic ulcer; Aloysia; antioxidant activity; ulcer index; Omeprazole | ||||
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