Efficacy and safety of platelet lysate mucoadhesive gel in the treatment of patients suffering from an erosive form of oral lichen planus: A randomized placebo-controlled clinical trial
Shalby, R., El Telbany, D., Hassan, S. (2022). Efficacy and safety of platelet lysate mucoadhesive gel in the treatment of patients suffering from an erosive form of oral lichen planus: A randomized placebo-controlled clinical trial. EKB Journal Management System, 68(4), 3261-3272. doi: 10.21608/edj.2022.146525.2166
Rania Shalby; Dalia El Telbany; Sandy Hassan. "Efficacy and safety of platelet lysate mucoadhesive gel in the treatment of patients suffering from an erosive form of oral lichen planus: A randomized placebo-controlled clinical trial". EKB Journal Management System, 68, 4, 2022, 3261-3272. doi: 10.21608/edj.2022.146525.2166
Shalby, R., El Telbany, D., Hassan, S. (2022). 'Efficacy and safety of platelet lysate mucoadhesive gel in the treatment of patients suffering from an erosive form of oral lichen planus: A randomized placebo-controlled clinical trial', EKB Journal Management System, 68(4), pp. 3261-3272. doi: 10.21608/edj.2022.146525.2166
Shalby, R., El Telbany, D., Hassan, S. Efficacy and safety of platelet lysate mucoadhesive gel in the treatment of patients suffering from an erosive form of oral lichen planus: A randomized placebo-controlled clinical trial. EKB Journal Management System, 2022; 68(4): 3261-3272. doi: 10.21608/edj.2022.146525.2166

Efficacy and safety of platelet lysate mucoadhesive gel in the treatment of patients suffering from an erosive form of oral lichen planus: A randomized placebo-controlled clinical trial

Egyptian Dental Journal
Article 6, Volume 68, Issue 4 - Serial Number 3, October 2022, Page 3261-3272  XML PDF (1023.82 K)
Document Type: Original Article
DOI: 10.21608/edj.2022.146525.2166
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Authors
Rania Shalby email orcid 1; Dalia El Telbanyorcid 2; Sandy Hassanorcid 3
1Lecturer at Oral Medicine, Diagnosis and Periodontology Department, Faculty of Dentistry, Fayoum University, Egypt
2Associate professor at Oral Medicine, Diagnosis and Periodontology Department, Faculty of Dentistry, Fayoum and Ahram Canadian Universities, Egypt
3Associate professor of Pharmaceutics, Faculty of Pharmacy, Modern University for Technology and Information (MTI), Cairo, Egypt
Abstract
Trial design: The study is a randomized clinical placebo-controlled trial in parallel groups 1:1 allocation ratio. Methods: 30 patients with erosive oral lichen planus were randomly assigned to receive either platelet lysate mucoadhesive gel or placebo vehicle gel 3 times per day for 4 weeks. Outcomes: Assessment of outcomes included a visual analog scale (VAS) for pain as a primary outcome, and the secondary outcomes included improvement in the clinical picture according to thongprasom sign score and any side effects of treatment. Results: results had shown a significant reduction of both pain and clinical scores in both groups at 2, 3, and 4 weeks and at 3 months of follow-up and a significant difference in pain and clinical scores between the intervention and control group at each visit as well as at 3 months follow up in which the intervention had greater pain reduction and clinical improvement. Conclusion: Platelet lysate mucoadhesive gel is a promising material for managing erosive OLP and could be considered a suitable, safe, and easy alternative to other hemo-derived products. However, further larger randomized controlled trials are recommended.
Keywords
Platelet lysate; Platelet-rich plasma; Platelet-derived growth factors; Oral lichen planus; Erosive oral lichen planus
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