Immunohistochemical expression of Lipocalin-2 and Matrix Metalloproteinase-9 in Oral Squamous Cell Carcinoma
Hafez, S., ElShamy, E., AbouZaid, B. (2022). Immunohistochemical expression of Lipocalin-2 and Matrix Metalloproteinase-9 in Oral Squamous Cell Carcinoma. EKB Journal Management System, 68(4), 3357-3367. doi: 10.21608/edj.2022.156112.2216
Samar Hafez; Eman ElShamy; Basant AbouZaid. "Immunohistochemical expression of Lipocalin-2 and Matrix Metalloproteinase-9 in Oral Squamous Cell Carcinoma". EKB Journal Management System, 68, 4, 2022, 3357-3367. doi: 10.21608/edj.2022.156112.2216
Hafez, S., ElShamy, E., AbouZaid, B. (2022). 'Immunohistochemical expression of Lipocalin-2 and Matrix Metalloproteinase-9 in Oral Squamous Cell Carcinoma', EKB Journal Management System, 68(4), pp. 3357-3367. doi: 10.21608/edj.2022.156112.2216
Hafez, S., ElShamy, E., AbouZaid, B. Immunohistochemical expression of Lipocalin-2 and Matrix Metalloproteinase-9 in Oral Squamous Cell Carcinoma. EKB Journal Management System, 2022; 68(4): 3357-3367. doi: 10.21608/edj.2022.156112.2216

Immunohistochemical expression of Lipocalin-2 and Matrix Metalloproteinase-9 in Oral Squamous Cell Carcinoma

Egyptian Dental Journal
Article 14, Volume 68, Issue 4 - Serial Number 3, October 2022, Page 3357-3367  XML PDF (3.02 MB)
Document Type: Original Article
DOI: 10.21608/edj.2022.156112.2216
View on SCiNiTO View on SCiNiTO
Authors
Samar Hafezorcid 1; Eman ElShamyorcid 2; Basant AbouZaid email orcid 2
1Oral Pathology Department, Faculty of Dentistry, Kafr El Sheikh University, Kafr El Sheikh, Egypt
2Oral Pathology Department, Faculty of Dentistry, Tanta University, Egyp
Abstract
Background: Oral squamous cell carcinoma (OSCC) is a well-known malignancy with diverse clinicopathological behavior and high mortality rate. It has great tendency to undergo lymph node metastasis. Its metastatic spread is highly regulated and entails the interplay of several factors released from cancer cells as well as stromal cells. Lipocalin-2 (LCN-2) is a secreted glycoprotein characterized by its involvement in inflammation, infection and cancer. Its role in oral cancer progression remains elusive. LCN-2 tends to form a complex with matrix metalloproteinase-9 (MMP-9), a well-known regulator of tumor microenvironment, enhancing its tumorigenic activity.
Objectives: This study aimed to investigate the immunohistochemical expression of LCN-2 and MMP-9 in OSCC.
Material and methods: The study was carried out on forty paraffin embedded archival OSCC specimens. The specimens were immunohistochemically stained against LCN-2 and MMP-9.
Results: Significant downregulation of LCN-2 expression was found in cancer cells with increased malignant criteria whereas stromal LCN-2 expression showed positive correlation with advanced histopathologic grade. Inverse correlation was observed between LCN-2 expression in both cancer and stromal with lymph node metastasis. MMP-9 expression was inversely correlated with the advanced histopathologic grades in both cancer and stromal cells.
Conclusion: The downregulation of LCN-2 and MMP-9 expressions in cancer cells with advanced OSCC histopathologic grade as well as at tumor invasive fronts propose their putative prognostic value.
Keywords
Oral squamous cell carcinoma (OSCC); Oral cancer; Lipocalin-2 (LCN-2); Matrix metalloproteinase-9 (MMP-9); immunohistochemistry
Statistics
Article View: 152
PDF Download: 97