The Efficacy of a Combination of Hyaluronic acid and Metronidazole as a topical Adjunctive in Non- Surgical Treatment of Periodontitis (Clinical and Biochemical Study)
Farag, L., Edrees, M., Ebrahim, E. (2022). The Efficacy of a Combination of Hyaluronic acid and Metronidazole as a topical Adjunctive in Non- Surgical Treatment of Periodontitis (Clinical and Biochemical Study). EKB Journal Management System, 5(2), 243-251. doi: 10.21608/aadj.2022.267322
Lamiaa Mohammed Farag; Mohamed F. Edrees; Ebrahim H. Ebrahim. "The Efficacy of a Combination of Hyaluronic acid and Metronidazole as a topical Adjunctive in Non- Surgical Treatment of Periodontitis (Clinical and Biochemical Study)". EKB Journal Management System, 5, 2, 2022, 243-251. doi: 10.21608/aadj.2022.267322
Farag, L., Edrees, M., Ebrahim, E. (2022). 'The Efficacy of a Combination of Hyaluronic acid and Metronidazole as a topical Adjunctive in Non- Surgical Treatment of Periodontitis (Clinical and Biochemical Study)', EKB Journal Management System, 5(2), pp. 243-251. doi: 10.21608/aadj.2022.267322
Farag, L., Edrees, M., Ebrahim, E. The Efficacy of a Combination of Hyaluronic acid and Metronidazole as a topical Adjunctive in Non- Surgical Treatment of Periodontitis (Clinical and Biochemical Study). EKB Journal Management System, 2022; 5(2): 243-251. doi: 10.21608/aadj.2022.267322

The Efficacy of a Combination of Hyaluronic acid and Metronidazole as a topical Adjunctive in Non- Surgical Treatment of Periodontitis (Clinical and Biochemical Study)

Al-Azhar Assiut Dental Journal
Article 12, Volume 5, Issue 2, October 2022, Page 243-251  XML PDF (1.6 MB)
Document Type: Original Article
DOI: 10.21608/aadj.2022.267322
View on SCiNiTO View on SCiNiTO
Authors
Lamiaa Mohammed Farag email ; Mohamed F. Edrees; Ebrahim H. Ebrahim
Department of Oral Medicine, Periodontology, Oral Diagnosis and Dental Radiology, Faculty of Dentistry, Al-Azhar University, Assiut, Egypt.
Abstract
Aim: This study was designed to evaluate the clinical and biochemical effects of combination of hyaluronic acid and metronidazole as an adjunctive treatment of periodontitis. Subjects and methods: Forty patients with stage I to stage II, grade A periodontitis were selected from the out-patient clinic, Oral Medicine and Periodontology Department, Faculty of Dental Medicine, Al-Azhar University, Assiut Branch. They were divided into four equal groups. Group I received conventional periodontal therapy alone, group II received conventional periodontal therapy with intra pocket application of hyaluronic acid gel (GENGIGEL) 0.2%, group III received conventional periodontal therapy with intra pocket application of metronidazole (25%) and group IV received conventional periodontal therapy with intra pocket application of combination of hyaluronic acid (0.2%) and metronidazole (25%). All patients were evaluated clinically at baseline, 3 and 6 months and biochemical evaluation was done at baseline,1 and 3 months to evaluate the IL-1β level in GCF. Results: All groups showed statistically significant differences at the different intervals in all clinical parameters (PI, GI, PD, CAL) and IL-1β level in GCF. Inter-groups comparison with respect to clinical and biochemical changes showed that Combination gel was the best. Conclusion: The combination of hyaluronic acid and metronidazole achieve superior effects as adjunctive therapy in improving the clinical and biochemical parameters in the treatment of periodontitis.
Keywords
Hyaluronic acid; Metronidazole; Topical Adjunctive; periodontitis; biochemical parameters
Statistics
Article View: 138
PDF Download: 339