In Vitro Anticancer and Antibacterial Assessment of Novel Metal Complexes of 1,3-di-[P-Tolyl]-2,4-di-[9H-Purin-6-Yl]-2,4- Dichlorocyclodiphosph(V)Azane
Hamed, A., Sharaby, C., Amine, M., Ammar, Y., El-Sherif, A. (2022). In Vitro Anticancer and Antibacterial Assessment of Novel Metal Complexes of 1,3-di-[P-Tolyl]-2,4-di-[9H-Purin-6-Yl]-2,4- Dichlorocyclodiphosph(V)Azane. EKB Journal Management System, 65(131), 843-857. doi: 10.21608/ejchem.2022.158055.6840
Asmaa A. Hamed; Carmen M. Sharaby; Mona F. Amine; Yousry A. Ammar; Ahmed A. El-Sherif. "In Vitro Anticancer and Antibacterial Assessment of Novel Metal Complexes of 1,3-di-[P-Tolyl]-2,4-di-[9H-Purin-6-Yl]-2,4- Dichlorocyclodiphosph(V)Azane". EKB Journal Management System, 65, 131, 2022, 843-857. doi: 10.21608/ejchem.2022.158055.6840
Hamed, A., Sharaby, C., Amine, M., Ammar, Y., El-Sherif, A. (2022). 'In Vitro Anticancer and Antibacterial Assessment of Novel Metal Complexes of 1,3-di-[P-Tolyl]-2,4-di-[9H-Purin-6-Yl]-2,4- Dichlorocyclodiphosph(V)Azane', EKB Journal Management System, 65(131), pp. 843-857. doi: 10.21608/ejchem.2022.158055.6840
Hamed, A., Sharaby, C., Amine, M., Ammar, Y., El-Sherif, A. In Vitro Anticancer and Antibacterial Assessment of Novel Metal Complexes of 1,3-di-[P-Tolyl]-2,4-di-[9H-Purin-6-Yl]-2,4- Dichlorocyclodiphosph(V)Azane. EKB Journal Management System, 2022; 65(131): 843-857. doi: 10.21608/ejchem.2022.158055.6840

In Vitro Anticancer and Antibacterial Assessment of Novel Metal Complexes of 1,3-di-[P-Tolyl]-2,4-di-[9H-Purin-6-Yl]-2,4- Dichlorocyclodiphosph(V)Azane

Egyptian Journal of Chemistry
Volume 65, Issue 131, December 2022, Page 843-857  XML PDF (924.2 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2022.158055.6840
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Authors
Asmaa A. Hamed email orcid 1; Carmen M. Sharabyorcid 2; Mona F. Amine2; Yousry A. Ammar3; Ahmed A. El-Sherif4
1Inorganic Chemistry, Faculty of Science for Girls, Al-Azhar University, Nasr City, Cairo
2Chemistry Department, Faculty of Science, Al-Azhar University (Girls), Nasr City, Cairo, Egypt
3Department of Chemistry, Faculty of Science, Al-Azhar University, Cairo
4organometallic Department of Chemistry, Faculty of Science, Cairo University, Cairo, Egypt
Abstract
Iron, copper, zinc, cadmium, and silver complexes of 1,3-di-[p-tolyl]-2,4-di-[9H-purin-6-yl]-2,4-dichlorocyclodiphosph(V)azane, H2L ligand were performed and characterized using spectroscopic and analytical techniques. The 1:2(L:M) complex structures of such complexes were revealed by spectroscopic analysis. The spectroscopic findings also suggested an octahedral structure for all complexes except for the tetrahedral silver complex. The ligand was coordinated to metal ions through exocyclic-NH and pyrimidine-N. Furthermore, computational studies of the H2L ligand were performed by the DFT/B3LYP methodology in which the ligand was improved. HOMO and LUMO energy values, chemical hardness, electronegativity, softness, and other parameters were calculated. The antitumor activity of all produced compounds was studied versus, human being breast carcinoma and human being colorectal carcinoma cell lines (MCF-7 & HCT-116). Additionally, antibacterial, and antifungal activity were also investigated.
Keywords
Nucleobase; cyclodiphosph(V)azane derivative; metal complexes; molecular modeling; antimicrobial; anticancer activity
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