Can Proton MR Spectroscopy Differentiate Multiple Sclerosis Plaques From White Matter Lesions Using Myo-Inositol/Creatine Ratio | ||||
| Zagazig University Medical Journal | ||||
| Article 17, Volume 29, Issue 3, May and June 2023, Page 880-888 PDF (353.67 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2022.149951.2599 | ||||
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| Authors | ||||
mai khamis  1; Dena Abd El Aziz El Sammak2
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| 1radiodiagnosis department, faculty of human medicine, zagazig university | ||||
| 2Radiology department zagazig university sharkia Egypt | ||||
| Abstract | ||||
| Object: To assess the significance of mI/Cr ratio obtained from MR spectroscopy in differentiating multiple sclerosis (MS) plaques from vascular associated white matter lesions (WML). Patients and Methods: This study included 23 patients with established diagnosis of relapsing remitting MS (15 females, 8 males, mean age 45±5.7 years) and 18 patients with ischemic WML (10 females, 8 male, mean age 59±5.9 years) who underwent MRI as diagnostic step in case of vascular insult like minor stroke and 12 normal control , all were examined with conventional MRI and single voxel MR spectroscopy. Metabolite ratios for Cho/Cr, Cho/NAA and MI/Cr were calculated automatically then compared between the three groups and compared between MS plaques and WML. Results: The mean ratio for mI/Cr were (1.57±0.37 , 0.90±0.13 and 0.65±0.05), Cho/Cr were (0.83±0.38, 0.79±0.18 and 1.04±0.07) and Cho/NAA were (0.74±0.33, 0.73±0.23 and 0.61±0.05) in MS plaques, WML and normal control WM (NCWM) respectively. Ms plaques showed significant increase in mI/Cr ratio in comparison to WML (p value | ||||
| Keywords | ||||
| MS; WML; mI/Cr ratio | ||||
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